Evidence map›Paper›PMID 30223424›Full record

ArticleInternational journal of molecular sciences2018

Phosphatidylethanolamine Induces an Antifibrotic Phenotype in Normal Human Lung Fibroblasts and Ameliorates Bleomycin-Induced Lung Fibrosis in Mice.

Luis G Vazquez-de-Lara, Beatriz Tlatelpa-Romero, Yair Romero, Nora Fernández-Tamayo, Fernando Vazquez-de-Lara, Jaime M Justo-Janeiro, Mario Garcia-Carrasco, René de-la-Rosa Paredes, José G Cisneros-Lira, Criselda Mendoza-Milla and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Altered Metabolism in Idiopathic Pulmonary Fibrosis.Journal of cellular physiology · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. The Role of Pulmonary Surfactant Phospholipids in Fibrotic Lung Diseases.International journal of molecular sciences · 2022
    Review
  15. Article
  16. Histamine activates an intracellular CaFrontiers in cell and developmental biology · 2022
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Luis G Vazquez-de-LaraFacultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla 72410, Mexico. luis.vazquezdelara@correo.buap.mx.ORCID 0000-0002-8219-2135
Beatriz Tlatelpa-RomeroFacultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla 72410, Mexico. beatlarom@outlook.com.
Yair RomeroFacultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla 72410, Mexico. yair12@hotmail.com.ORCID 0000-0002-8707-025X
Nora Fernández-TamayoFacultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla 72410, Mexico. norafertamayo@gmail.com.
Fernando Vazquez-de-LaraFacultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla 72410, Mexico. fvazdela@gmail.com.
Jaime M Justo-JaneiroHospital General del Sur, Puebla 72490, Mexico. jaime_justo@hotmail.com.
Mario Garcia-CarrascoFacultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla 72410, Mexico. mgc30591@yahoo.com.
René de-la-Rosa ParedesHospital General del Sur, Puebla 72490, Mexico. rdelarosa2000@hotmail.com.
José G Cisneros-LiraInstituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", México City 14080, Mexico. jgclira@yahoo.com.mx.
Criselda Mendoza-MillaInstituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", México City 14080, Mexico. criselda.mendoza@gmail.com.
Francesco MocciaLaboratory of General Physiology, Department of Biology and Biotechnology ''Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy. francesco.moccia@unipv.it.ORCID 0000-0003-0010-0098
Roberto Berra-RomaniFacultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla 72410, Mexico. rberra001@hotmail.com.ORCID 0000-0003-4884-0925
Benemérita Universidad Autónoma de Puebla · MXInstituto Nacional de Enfermedades Respiratorias · MXUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung surfactant is a complex mixture of phospholipids and specific proteins but its role in the pathogenesis of interstitial lung diseases is not established. Herein, we analyzed the effects of three representative phospholipid components, that is, dipalmitoilphosphatidylcoline (DPPC), phosphatidylglycerol (PG) and phosphatidylethanolamine (PE), on collagen expression, apoptosis and Ca

Indexed as

AnimalsApoptosisBleomycinCalciumCalcium SignalingCollagenDisease Models, AnimalDose-Response Relationship, DrugFemaleFibroblastsGene ExpressionGene Expression RegulationHumansMaleMicePhosphatidylethanolaminesBleomycinCalciumCollagenphosphatidylethanolaminePhosphatidylethanolaminesPulmonary Surfactantsbleomycin modelCa2+ signalinglung fibroblastslung fibrosisphosphatidylethanolaminepulmonary surfactant

Identifiers

PMID30223424
PMCPMC6164566
OpenAlexW2890327305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.