Evidence map›Paper›PMID 30223401›Full record

ArticleJournal of neuromuscular diseases2018

Motor Function Test Reliability During the NeuroNEXT Spinal Muscular Atrophy Infant Biomarker Study.

Kristin J Krosschell, Michael Bosch, Leslie Nelson, Tina Duong, Linda P Lowes, Lindsay N Alfano, Danielle Benjamin, Terri B Carry, Ginger Devine, Carolyn Kelley and 19 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuromuscular diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Functional movement assessment with the Test of Infant Motor Performance.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Review
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 18 institutions in 1 country.

Kristin J KrosschellDepartment of Physical Therapy and Human Movement Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Michael BoschDepartment of Biostatistics, NeuroNEXT Data Coordinating Center, University of Iowa, Iowa City, IA, USA.
Leslie NelsonPhysical Therapy, UT Southwestern Medical Center, Dallas, TX, USA.
Tina DuongDepartment of Neurology, Stanford University, Palo Alto, CA, USA.
Linda P LowesNeurology, Nationwide Children's Hospital, Columbus, OH, USA.
Lindsay N AlfanoNeurology, Nationwide Children's Hospital, Columbus, OH, USA.
Danielle BenjaminPhysical Therapy, Oregon Health and Science University, Portland, OR, USA.
Terri B CarryPhysical Therapy, Children's Hospital Colorado, Aurora, CO, USA.
Ginger DevinePi Beta Phi Rehabilitation Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Carolyn KelleyPhysical Therapy, Children's Hospital Colorado, Aurora, CO, USA.
Rebecca GadekanNeuromuscular Division, Washington University School of Medicine, St. Louis, MO, USA.
Elizabeth C MalkusUltragenyx, Novato, CA, USA.
Amy PasternakThe Department of Physical Therapy and Occupational Therapy Services, Boston Children's Hospital, Boston, MA, USA.
Stephanie Provance-OrrPhysical and Occupational Therapy, Children's Mercy Hospital, Kansas City, MO, USA.
Lynne Roemeiser-LoganSUNY Upstate Medical University, Syracuse, NY, USA.
Alina NicoriciPhysical Medicine and Rehabilitation, University of California - Davis, Davis, CA, USA.
Donata TrussellUniversity of Utah, Salt Lake City, UT, USA.
Sally Dunaway YoungDepartments of Neurology and Rehabilitation and Regenerative Medicine, Columbia University Medical Center, New York, NY, USA.
Jennifer R FettermanSUNY Upstate Medical University, Syracuse, NY, USA.
Jacqueline MontesDepartments of Neurology and Rehabilitation and Regenerative Medicine, Columbia University Medical Center, New York, NY, USA.
Penny J PowersPi Beta Phi Rehabilitation Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Rebecca QuinonesPhysical and Occupational Therapy, Duke Health, Durham, NC, USA.
Janet QuigleyThe Department of Physical Therapy and Occupational Therapy Services, Boston Children's Hospital, Boston, MA, USA.
Christopher S CoffeyDepartment of Biostatistics, NeuroNEXT Data Coordinating Center, University of Iowa, Iowa City, IA, USA.
Jon W YankeyDepartment of Biostatistics, NeuroNEXT Data Coordinating Center, University of Iowa, Iowa City, IA, USA.
Amy BartlettDepartment of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
John T KisselDepartment of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Stephen J KolbDepartment of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
NeuroNEXT Clinical Trial Network and on behalf of the NN101 SMA Biomarker Investigators
The Ohio State University Wexner Medical Center · USUniversity of Iowa · USBoston Children's Hospital · USChildren's Hospital Colorado · USColumbia University Irving Medical Center · USNationwide Children's Hospital · USSUNY Upstate Medical University · USVanderbilt University Medical Center · USChildren's Mercy Hospital · USDuke University Health System · USNorthwestern University · USOregon Health & Science University · USPalo Alto University · USSouthwestern Medical Center · USUltragenyx Pharmaceutical (United States) · USUniversity of California, Davis · USUniversity of Utah · USWashington University in St. Louis · US

Funding

Clinical Coordinating Center Network of Excellence in Neuroscience Clinical TrialU01NS077179 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Merit E CUDKOWICZ, Aleksandar Videnovic · 2011 to 2026
$43.4M
Network of Excellence in Neuroscience Clinical Trials (NEXT)-DCCU01NS077352 · NINDS · UNIVERSITY OF IOWA · PI CHRISTOPHER S. COFFEY · 2011 to 2026
$28.1M
SMA Biomarkers in the Immediate Post-natal Period of DevelopmentU01NS079163 · NINDS · OHIO STATE UNIVERSITY · PI KOLB, STEPHEN J. · 2012 to 2014
$2.1M
NINDS NIH HHS U01 NS077179NINDS NIH HHS U01 NS077352NINDS NIH HHS U01 NS079163
6 · The paper itself

Abstract

backgroundThe NeuroNEXT SMA Infant Biomarker Study, a two year, longitudinal, multi-center study of infants with SMA type 1 and healthy infants, presented a unique opportunity to assess multi-site rater reliability on three infant motor function tests (MFTs) commonly used to assess infants with SMA type 1.

objectiveTo determine the effect of prospective MFT rater training and the effect of rater experience on inter-rater and intra-rater reliability for the Test of Infant Motor Performance Screening Items (TIMPSI), the Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP-INTEND) and the Alberta Infant Motor Scale (AIMS).

methodsTraining was conducted utilizing a novel set of motor function test (MFT) videos to optimize accurate MFT administration and reliability for the study duration. Inter- and intra-rater reliability of scoring for the TIMPSI and inter-rater reliability of scoring for the CHOP INTEND and the AIMS was assessed using intraclass correlation coefficients (ICC). Effect of rater experience on reliability was examined using ICC. Agreement with 'expert' consensus scores was examined using Pearson's correlation coefficients.

resultsInter-rater reliability on all MFTs was good to excellent. Intra-rater reliability for the primary MFT, the TIMPSI, was excellent for the study duration. Agreement with 'expert' consensus was within predetermined limits (≥85%) after training. Evaluator experience with SMA and MFTs did not affect reliability.

conclusionsReliability of scores across evaluators was demonstrated for all three study MFTs and scores were reproducible on repeated administration. Evaluator experience had no effect on reliability.

Indexed as

Clinical CompetencePhysical TherapistsBiomarkersFemaleHumansInfantLongitudinal StudiesMaleMotor ActivityReproducibility of ResultsSpinal Muscular Atrophies of ChildhoodBiomarkersAIMSCHOP-INTENDclinical evaluatormotor function testingneuromuscular diseasesNeuroNEXToutcome measuresreliabilitySpinal muscular atrophyTIMPSI

Identifiers

PMID30223401
PMCPMC8112280
OpenAlexW2891453491

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.