Evidence map›Paper›PMID 30223379›Full record

ArticleInternational journal of cardiology2018

Myocardial fibrosis and its relation to adverse outcome in transposition of the great arteries with a systemic right ventricle.

Craig S Broberg, Anne Marie Valente, Jennifer Huang, Luke J Burchill, Jonathan Holt, Ryan Van Woerkom, Andrew J Powell, George A Pantely, Michael Jerosch-Herold

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 39 citations in OpenAlex.

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  9. Longitudinal changes in systemic right ventricular remodeling in adult patients with transposition of the great vessels as assessed by cardiovascular magnetic resonance imaging.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024
    Article
  10. Ventricular arrhythmia in congenital heart diseases with a systemic right ventricle.International journal of cardiology. Congenital heart disease · 2023
    Review
  11. Article
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  19. Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Craig S BrobergAdult Congenital Heart Disease Program, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, United States. Electronic address: brobergc@ohsu.edu.
Anne Marie ValenteDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: Anne.Valente@cardio.chboston.org.
Jennifer HuangDivision of Pediatric Cardiology, Oregon Health & Science University, Portland, OR, United States. Electronic address: huangje@ohsu.edu.
Luke J BurchillAdult Congenital Heart Disease Program, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, United States.
Jonathan HoltAdult Congenital Heart Disease Program, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, United States. Electronic address: holjo@ohsu.edu.
Ryan Van WoerkomAdult Congenital Heart Disease Program, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, United States. Electronic address: vanwoerr@ohsu.edu.
Andrew J PowellDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: andrew.powell@cardio.chboston.org.
George A PantelyAdult Congenital Heart Disease Program, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, United States. Electronic address: pantelyg@ohsu.edu.
Michael Jerosch-HeroldDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Oregon Health & Science University · USBoston Children's Hospital · USBrigham and Women's Hospital · US

Funding

Oregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7M
Heart Failure in Congenital Heart Disease: The role of Myocardial FibrosisK23HL093024 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI BROBERG, CRAIG STANFORD · 2009 to 2013
$655k
NCATS NIH HHS UL1 TR000128NHLBI NIH HHS K23 HL093024
6 · The paper itself

Abstract

backgroundMyocardial dysfunction has been implicated in gradual heart failure in transposition of the great arteries (TGA) with a systemic right ventricle (RV). Fibrosis can be assessed using the extracellular volume fraction (ECV). Our aim was to measure ECV and determine its associations with clinical findings and outcomes.

methodsWe prospectively measured ECV in systemic RV subjects (either D-loop after atrial switch or L-loop) and healthy controls. T

resultsIn 53 TGA subjects (age 34.6 ± 10.3 years, 41% female) the mean ECV for the systemic RV (28.7 ± 4.4%) was significantly higher than the left ventricle in 22 controls (26.1 ± 2.8%, P = 0.0104). Those with an elevated ECV (n = 15, 28.3%) had a higher b-type natriuretic peptide (BNP) (P < 0.011) and a longer 6-min walk distance (P = 0.021), but did not differ by age, arrhythmia history, ventricular volume, function, or circulating collagen byproducts. At follow-up (median 4.4 years), those experiencing major cardiovascular endpoints (new arrhythmia, arrhythmia device, heart failure hospitalization, listing for transplantation, mechanical support, or cardiovascular death, n = 14) had a higher ECV. ECV, age, and BNP were independent predictors of cardiac events in Cox-proportional hazard models.

conclusionsMyocardial fibrosis is common in the systemic RV and associated with a higher BNP. Elevated CMR-derived ECV was associated with adverse clinical outcome. The findings suggest a role of diffuse myocardial fibrosis in clinical deterioration of the systemic RV.

Indexed as

AdultFemaleFibrosisFollow-Up StudiesHeart FailureHumansMaleMiddle AgedMyocardiumProspective StudiesTransposition of Great VesselsTreatment OutcomeVentricular Dysfunction, RightCardiac magnetic resonanceCongenital heart diseaseMyocardial fibrosisSystemic right ventricleTransposition of the great arteriesVentricular dysfunction

Identifiers

PMID30223379
PMCPMC6146411
OpenAlexW2889174329

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.