ArticleJournal of affective disorders2019
The role of substance use, smoking, and inflammation in risk for suicidal behavior.
Article in Journal of affective disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Role of machine learning algorithms in suicide risk prediction: a systematic review-meta analysis of clinical studies.BMC medical informatics and decision making · 2024Pooled it
- Pooled it
- Systemic Biomarker Alterations in Alcohol and Psychoactive Substance Users: A Cross-Sectional Study.Biomolecules · 2026Article
- Gender differences in gray matter volume of the anterior cingulate cortex and suicidal ideation in patients with major depressive disorder: evidence from the REST-meta-MDD project.Translational psychiatry · 2025Article
- Role of peripheral cytokines and orbitofrontal cortex subregion structure in schizophrenia agitation.Scientific reports · 2025Article
- Methadone and Buprenorphine as Medication for Addiction Treatment Diversely Affect Inflammation and Craving Depending on Their Doses.Pharmacy (Basel, Switzerland) · 2025Article
- Predictors of suicidal behavior in a sample of incarcerated individuals.Trends in psychiatry and psychotherapy · 2025Observational
- Suicide, neuroinflammation and other physiological alterations.European archives of psychiatry and clinical neuroscience · 2024Review
- Suicide mortality following the implementation of tobacco packaging and pricing policies in Korea: an interrupted time-series analysis.BMC medicine · 2024Article
- Network analysis of comorbid depression, suicidality and biomarkers on HPA axis among mood disorder patients to psychiatric emergency services.Translational psychiatry · 2023Article
- Plasma and cerebrospinal fluid inflammatory markers and human aggression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- A moderated mediation analysis of the association between smoking and suicide attempts among adolescents in 28 countries.Scientific reports · 2023Article
- Association of combined healthy lifestyle with general and abdominal obesity.Frontiers in nutrition · 2023Article
- Sibling alcohol use disorder is associated with increased risk for suicide attempt.Clinical psychological science : a journal of the Association for Psychological Science · 2022Article
- Suicidal ideation and behavior in youth in low- and middle-income countries: A brief review of risk factors and implications for prevention.Frontiers in psychiatry · 2022Review
- Resting mononuclear cell NR3C1 and SKA2 expression levels predict blunted cortisol reactivity to combat training stress among elite army cadets exposed to childhood adversity.Molecular psychiatry · 2021Article
- A genetically informed study on the association of cannabis, alcohol, and tobacco smoking with suicide attempt.Molecular psychiatry · 2021Article
- Psychosocial Correlates of Suicidal Behavior among Adolescents under Confinement Due to the COVID-19 Pandemic in Aguascalientes, Mexico: A Cross-Sectional Population Survey.International journal of environmental research and public health · 2021Article
- The role of psychiatric symptoms and environmental vulnerability factors in explaining the relationship between child maltreatment and suicidality: A prospective investigation.Journal of affective disorders · 2020Article
- Post-trauma anhedonia is associated with increased substance use in a recently-traumatized population.Psychiatry research · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlcohol and substance use disorders are important predictors for suicidal behavior. However, the role of individual substances as proximal risk factors for suicidal behavior and the mechanisms through which substance use affect risk are not entirely clear. We examine whether the frequency of substance use and whether biological markers in the HPA axis and inflammatory pathways are associated with clinical risk factors of suicidal behavior of aggression, impulsivity, hopelessness, and poor sleep.
methodsThe sample consisted of psychiatric inpatients, aged 15-30 years, admitted for suicide attempt (n = 38), suicidal ideation (n = 40); and healthy controls (n = 37). We measured hair cortisol concentrations, glucocorticoid receptor (GR) sensitivity, stimulated production of interleukin- or IL-6, C-reactive protein, and mRNA expression of GR, SKA2, FKBP5, TNF-α, and IL-1β.
resultsSmoking was associated with increased aggression [β = 2.9, 95% CI (-0.03, 6), p = 0.05], impulsivity [β = 3.1, 95% CI (1.6, 4.6), p < 0.001], and poor sleep [β = 0.5, 95% CI (0.03, 0.95), p = 0.04] even after controlling for demographics and group. Similarly, TNF-α mRNA was associated with impulsivity [β = 0.07, 95% CI (0.01, 0.1), p = 0.02] and hopelessness [β = 0.03, 95% CI (0.004, 0.05), p = 0.03]. Smoking tobacco (r = 0.32, p < 0.001) was positively associated with TNF-α mRNA. LIMITATIONS: Study limitations include the cross-sectional design, retrospective assessment, and relatively small sample size.
conclusionsFuture longitudinal studies are needed to test whether inflammatory markers mediate the relationships between smoking, clinical risk factors, and suicidal behavior; and to examine whether smoking cessation could reduce the risk for suicidal behavior in at-risk patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.