Evidence map›Paper›PMID 30223066›Full record

ReviewCancer letters2018

Regulation of sex hormone receptors in sexual dimorphism of human cancers.

Daoshan Zheng, Cecilia Williams, Jeremy A Vold, Justin H Nguyen, Denise M Harnois, Sanjay P Bagaria, Sarah A McLaughlin, Zhaoyu Li

Abstract readReview
In one paragraph

Review in Cancer letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. GPCRs and fibroblast heterogeneity in fibroblast-associated diseases.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Review
  4. Review
  5. Colitis Induces Sex-Specific Intestinal Transcriptomic Responses in Mice.International journal of molecular sciences · 2022
    Article
  6. ERβ and Inflammation.Advances in experimental medicine and biology · 2022
    Article
  7. Article
  8. Review
  9. X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020
    Review
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daoshan ZhengDepartment of Cancer Biology, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
Cecilia WilliamsDepartment of Biosciences and Nutrition, KTH Royal Institute of Technology, Karolinska Institutet, Science for Life Laboratory, Stockholm, Sweden.
Jeremy A VoldMayo Cancer Registry, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
Justin H NguyenDepartment of Surgery, and Mayo Clinic Cancer Center, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
Denise M HarnoisDepartment of Surgery, and Mayo Clinic Cancer Center, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
Sanjay P BagariaDepartment of Surgery, and Mayo Clinic Cancer Center, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
Sarah A McLaughlinDepartment of Surgery, and Mayo Clinic Cancer Center, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.
Zhaoyu LiDepartment of Cancer Biology, 4500 San Pablo Road, Jacksonville, FL, 32224, USA. Electronic address: li.zhaoyu@mayo.edu.

Funding

Elucidating the mechanism of ERbeta in colon carcinogenesisR01CA172437 · NCI · UNIVERSITY OF HOUSTON · PI WILLIAMS, CECILIA MARIE · 2013 to 2018
$1.4M
Comparative Genomics Study of Foxa/ER Targets in Liver Cancer and Breast CancerR00CA168983 · NCI · MAYO CLINIC JACKSONVILLE · PI LI, ZHAOYU · 2013 to 2015
$725k
NCI NIH HHS R00 CA168983NCI NIH HHS R01 CA172437
6 · The paper itself

Abstract

Gender differences in the incidences of cancers have been found in almost all human cancers. However, the mechanisms that underlie gender disparities in most human cancer types have been under-investigated. Here, we provide a comprehensive overview of potential mechanisms underlying sexual dimorphism of each cancer regarding sex hormone signaling. Fully addressing the mechanisms of sexual dimorphism in human cancers will greatly benefit current development of precision medicine. Our discussions of potential mechanisms underlying sexual dimorphism in each cancer will be instructive for future cancer research on gender disparities.

Indexed as

Signal TransductionFemaleGonadal Steroid HormonesHumansMaleNeoplasmsPrecision MedicineReceptors, SteroidSex FactorsGonadal Steroid HormonesReceptors, SteroidAndrogen receptorCancer incidenceEstrogen receptorSex hormonesSexual dimorphism

Identifiers

PMID30223066
PMCPMC6287770

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.