ArticlePloS one2018
Copper-caused oxidative stress triggers the activation of antioxidant enzymes via ZmMPK3 in maize leaves.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 116 citations in OpenAlex.
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- Copper causes reduced nitrogen fixation but does not accumulate in the nodules of the legume Lotus japonicus.PloS one · 2026Article
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- Farmyard manure, a potential organic additive to reclaim copper and Macrophomina phaseolina stress responses in mash bean plants.Scientific reports · 2023Article
- Beauveria bassiana rewires molecular mechanisms related to growth and defense in tomato.Journal of experimental botany · 2023Article
- Effects of four disease-controlling agents (chlorothalonil, CuClScientific reports · 2023Article
- Physiological and Biochemical Properties of Cotton Seedlings in Response to CuCurrent issues in molecular biology · 2023Article
- Exogenous Proline Enhances Systemic Defense against Salt Stress in Celery by Regulating Photosystem, Phenolic Compounds, and Antioxidant System.Plants (Basel, Switzerland) · 2023Article
- Screening and Verification of Reference Genes for Analysis of Gene Expression in Garlic (Plants (Basel, Switzerland) · 2023Article
- Copper boosts the biostimulant activity of a vegetal-derived protein hydrolysate in basil: morpho-physiological and metabolomics insights.Frontiers in plant science · 2023Article
- Delta SARS-CoV-2 inactivation and bactericidal performance of cotton wipes decorated with TiOMaterials today. Communications · 2022Article
- Biochemical Insights into the Ability ofPlants (Basel, Switzerland) · 2022Article
- Questioning ZnO, Ag, and Ag/ZnO nanoparticles as antimicrobial agents for textiles: Do they guarantee total protection against bacteria and SARS-CoV-2?Journal of photochemistry and photobiology. B, Biology · 2022Article
- Phytoremediation of copper-contaminated soil by Artemisia absinthium: comparative effect of chelating agents.Environmental geochemistry and health · 2022Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Copper (Cu) is a necessary trace element participated in many physiological processes in plants. But excessive Cu2+ is toxic, which can activate intracellular signals that lead to cellular damage. The mitogen-activated protein kinase (MAPK) cascade is at the center of cell signal transduction and has been reported to be involved in stress-related signaling pathways. ZmMPK3, a kind of MAPKs in maize cells, can be activated by diverse abiotic stresses. In the present study, we investigated the effects of Cu2+ on hydrogen peroxide (H2O2) level, ZmMPK3 activity as well as the activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and ascorbic acid peroxidase (APX) using maize leaf as an experimental model. The results demonstrated that acute Cu2+ exposure for 24 hours led to rapid increases of H2O2 level and the increase in ZmMPK3 activity as well as the total activities of antioxidant enzymes SOD, CAT and APX. H2O2 scavenger, dimethylthiourea (DMTU), effectively inhibited the Cu2+-increased H2O2 level and the activity of ZmMPK3 as well as the activities of the antioxidant enzymes SOD, CAT and APX. Pre-treatment with the MAPK inhibitor, PD98059, significantly blocked the Cu2+-increased activities of ZmMPK3, CAT, APX and SOD, but didn't affect the accumulation of H2O2. Our results suggest that Cu2+ causes oxidative stress to the maize leaves which then activates defense antioxidant enzymes via MAPK pathway. Thus, the signaling pathway is Cu2+-H2O2-ZmMPK3-antioxidant enzymes.
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