Evidence map›Paper›PMID 30222661›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2018

Identification of a Syndemic of Blood-Borne Disease Transmission and Injection Drug Use Initiation at the US-Mexico Border.

Claudia Rafful, Sonia Jain, Xiaoying Sun, Steffanie A Strathdee, Richard S Garfein, Jazmine Cuevas-Mota, Carlos Magis-Rodríguez, Laramie R Smith, Dan Werb

Abstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Pediatric meningitis due toTherapeutic advances in infectious disease
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Claudia RaffulDivision of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, CA.
Sonia JainDepartment of Family Medicine and Public Health, Biostatistics Research Center, University of California San Diego, La Jolla, CA.
Xiaoying SunDepartment of Family Medicine and Public Health, Biostatistics Research Center, University of California San Diego, La Jolla, CA.
Steffanie A StrathdeeDivision of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, CA.
Richard S GarfeinDivision of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, CA.
Jazmine Cuevas-MotaDivision of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, CA.
Carlos Magis-RodríguezCentro Nacional para la Prevención y el Control del VIH y el SIDA (CENSIDA), Anzures, Mexico City, Mexico.
Laramie R SmithDivision of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, CA.
Dan WerbDivision of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, CA.

Funding

Impact of Drug Policy Reform on the HIV Risk Environment among IDUs in TijuanaR37DA019829 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI STRATHDEE, STEFFANIE A. · 2010 to 2019
$6.7M
Interdisciplinary Research Training Institute on Hispanic Drug AbuseR25DA026401 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VALDEZ, AVELARDO · 2009 to 2019
$3.2M
Drug tourism to Mexico: Impact of Mexicos new drug law on HIV-HCV-TB in US IDUsR01DA031074 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARFEIN, RICHARD S · 2011 to 2015
$3.2M
Preventing HIV by modifying the context for injecting initiationDP2DA040256 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WERB, DANIEL M · 2015 to 2015
$2.3M
HIV Treatment and Substance Use in LMIC Shaping MSMs Sociostructural ContextK01DA039767 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMITH, LARAMIE RAE · 2015 to 2019
$906k
CIHRNIDA NIH HHS DP2 DA040256NIDA NIH HHS K01 DA039767NIDA NIH HHS R01 DA031074NIDA NIH HHS R25 DA026401NIDA NIH HHS R37 DA019829
6 · The paper itself

Abstract

backgroundEfforts to prevent injection drug use (IDU) are increasingly focused on the role that people who inject drugs (PWID) play in the assistance with injection initiation. We studied the association between recent (ie, past 6 months) injection-related HIV risk behaviors and injection initiation assistance into IDU among PWID in the US-Mexico border region.

settingPreventing Injecting by Modifying Existing Responses (PRIMER) is a multicohort study assessing social and structural factors related to injection initiation assistance. This analysis included data collected since 2014 from 2 participating cohorts in San Diego and Tijuana.

methodsParticipants were 18 years and older and reported IDU within the month before study enrollment. Logistic regression analyses were conducted to assess the association between recent injection-related HIV risk behaviors (eg, distributive/receptive syringe sharing, dividing drugs in a syringe, and paraphernalia sharing) and recent injection initiation assistance.

resultsAmong 892 participants, 41 (4.6%) reported recently providing injection initiation assistance. In multivariable analysis adjusting for potential confounders, reporting a higher number of injection-related risk behaviors was associated with an increased odds of recently assisting others with injection initiation (adjusted odds ratio per risk behavior: 1.3; 95% confidence interval: 1.0 to 1.6, P = 0.04).

conclusionsPWID who recently engaged in one or more injection-related HIV risk behavior were more likely to assist others in injection initiation. These results stress the syndemic of injection initiation and risk behaviors, which indicates that prevention of injection-related HIV risk behaviors might also reduce the incidence of injection initiation.

Indexed as

Disease Transmission, InfectiousSyndemicAdultCohort StudiesFemaleHIV InfectionsHumansIncidenceMaleMexicoMiddle AgedNeedle SharingRisk-TakingSubstance Abuse, IntravenousUnited States

Identifiers

PMID30222661
PMCPMC6231973

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.