ArticleTechnology in cancer research & treatment2018
Definitive Radiotherapy With SBRT or IMRT Boost for Breast Cancer: Excellent Local Control and Cosmetic Outcome.
Article in Technology in cancer research & treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Phase I study of stereotactic ablative radiotherapy (SABR) in inoperable breast cancer.Breast (Edinburgh, Scotland) · 2026Article
- Article
- Baseline cross-sectional imaging of locally advanced high-risk breast cancer facilitates highly customized radiation therapy in surgically inaccessible anatomical areas.Frontiers in oncology · 2025Article
- Changes in Intratumor Blood Flow After Carbon-Ion Radiation Therapy for Early-Stage Breast Cancer.International journal of particle therapy · 2024Article
- Treatment Options for Early Stage Inoperable Breast Cancer: Cryoablation or Radiotherapy?Breast care (Basel, Switzerland) · 2024Review
- Non-Surgical Definitive Treatment for Operable Breast Cancer: Current Status and Future Prospects.Cancers · 2023Review
- Simultaneous integrated boost within the lymphatic drainage system in breast cancer: A single center study on toxicity and oncologic outcome.Frontiers in oncology · 2023Article
- Definitive radiotherapy with stereotactic or IMRT boost with or without radiosensitization strategy for operable breast cancer patients who refuse surgery.Journal of radiation research · 2022Article
- Primary Chemoradiotherapy Treatment (PCRT) for HER2+ and Triple Negative Breast Cancer Patients: A Feasible Combination.Cancers · 2022Article
- Review
- Effect of Narrative Nursing on Family Resilience and Psychosocial Adaptation of Middle-Aged Patients with Breast Cancer.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Helical tomotherapy for asymptomatic chemotherapy-refractory or -unfit multiple (3 or more) metastases.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022Article
- Dosimetric variation in preoperative partial breast radiosurgery assessed by deformable image registrations.Journal of radiosurgery and SBRT · 2022Article
- New enzyme-targeting radiosensitizer (KORTUC II) treatment for locally advanced or recurrent breast cancer.Molecular and clinical oncology · 2021Article
- Local radiotherapy for pleural dissemination of thymic tumors after initial treatment.Journal of radiation research · 2021Article
- Evaluation of overall survival and barriers to surgery for patients with breast cancer treated without surgery: a National Cancer Database analysis.NPJ breast cancer · 2021Article
- Using flattening filter free beams in electronic tissue compensation whole breast irradiation with deep inspiration breath hold.Journal of applied clinical medical physics · 2020Article
- A clinical study of curative partial breast irradiation for stage I breast cancer using carbon ion radiotherapy.Radiation oncology (London, England) · 2020Article
- Breast radiotherapy in elderly women: myths, controversies, and current techniques in the adjuvant setting.Translational cancer research · 2020Review
- Stereotactic radiation therapy for breast cancer in the elderly.Translational cancer research · 2020Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gold standard for breast cancer treatment is surgery, but many women may desire to avoid surgery if possible. The purpose of this study was to evaluate whether breast cancer could be cured with modern sophisticated radiation techniques with good cosmetic outcome. We have treated 18 patients with operable breast cancer by conventional whole-breast irradiation followed by stereotactic body radiotherapy (primary tumor only) or intensity-modulated radiotherapy (tumor plus axillary nodes) boost. The planned doses were 50 Gy in 25 fractions, 18 to 25.5 Gy in 3 fractions, and 20 Gy in 8 fractions, respectively, for the 3 modalities. Stereotactic body radiotherapy was delivered with 7 to 9 coplanar and noncoplanar fixed beams, and intensity-modulated radiotherapy was given by tomotherapy. Chemotherapy and/or hormone therapy was used depending on the stage and receptor status. In 9 recent patients, hydrogen peroxide was intratumorally injected twice a week before whole-breast irradiation. All treatments were well tolerable and there were no grade ≥3 toxicities. With a median follow-up period of 35 months (range, 8-120 months), only 1 patient developed local recurrence and 2 patients developed distant metastasis. Overall survival, progression-free survival, and local control rates were 93%, 85%, and 92%, respectively, at 3 years. In 50% of the patients, the irradiated breast became better rounded, and the position of the nipple of the irradiated breast became ≥1 cm higher compared to that of the unirradiated breast. Thus, the treated breasts may be more aesthetically favorable than before irradiation in these patients. This may become a treatment option for patients with operable breast cancer.
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