ArticleSmall (Weinheim an der Bergstrasse, Germany)2018
Investigating Subcellular Compartment Targeting Effect of Porous Coordination Cages for Enhancing Cancer Nanotherapy.
Article in Small (Weinheim an der Bergstrasse, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 57 citations in OpenAlex.
- Coordination sphere interactions drive isomer selection in heteroleptic Pd(ii) cages with low-symmetry ligands.Chemical science · 2025Article
- A Highly Charged Positive Cage Causes Simultaneous Enhancement of Type-II and OSmall science · 2024Article
- Comparing organic and metallo-organic hydrazone molecular cages as potential carriers for doxorubicin delivery.Chemical science · 2024Article
- Water-Soluble Molecular Cages for Biological Applications.Molecules (Basel, Switzerland) · 2024Review
- Biomedical Applications of Sulfonylcalix[4]arene-Based Metal-Organic Supercontainers.Molecules (Basel, Switzerland) · 2024Review
- Improving the gas sorption capacity in lantern-type metal-organic polyhedra by a scrambled cage method.Chemical science · 2024Article
- Investigating the Cell Entry Mechanism, Disassembly, and Toxicity of the Nanocage PCC-1: Insights into Its Potential as a Drug Delivery Vehicle.Journal of the American Chemical Society · 2023Article
- Porous Framework Materials for Bioimaging and Cancer Therapy.Molecules (Basel, Switzerland) · 2023Review
- Superparamagnetic iron oxide-gold nanoparticles conjugated with porous coordination cages: Towards controlled drug release for non-invasive neuroregeneration.Nanomedicine : nanotechnology, biology, and medicine · 2021Article
- Recent advances in porous nanostructures for cancer theranostics.Nano today · 2021Article
- Design and Applications of Water-Soluble Coordination Cages.Chemical reviews · 2020Article
- Controlled hierarchical self-assembly of networked coordination nanocapsulesChemical science · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Understanding the key factors for successful subcellular compartment targeting for cargo delivery systems is of great interest in a variety of fields such as bionanotechnology, cell biology, and nanotherapies. However, the fundamental basis for intracellular transportation with these systems has thus far rarely been discussed. As a cargo vector, porous coordination cages (PCCs) have great potential for use in cancer nanotherapy and to elucidate fundamental insight regarding subcellular compartment targeting. Herein, it is shown that the transportation of PCC cargo vectors though various subcellular barriers of the mammalian cell can be manipulated by tuning the vector's electronic property and surface affinity. It is found that the PCCs become selectively aggregated at the cell membrane, the cytoplasm, or the nucleus, respectively. When a DNA topoisomerase inhibitor is delivered into the nucleus by a neutral and lipophilic PCC, the anticancer efficacy is dramatically improved. The findings shed light to tune the interactions at the "bio-nano" interface. This study provides a key strategy for future work in targeting specific cell organelles for cell imaging, cargo delivery, and therapy. This research also offers key insight into the engineering of nanoscopic materials for furnishing cell organelle-specificity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.