Evidence map›Paper›PMID 30222109›Full record

ArticleeLife2018

The microtubule polymerase Stu2 promotes oligomerization of the γ-TuSC for cytoplasmic microtubule nucleation.

Judith Gunzelmann, Diana Rüthnick, Tien-Chen Lin, Wanlu Zhang, Annett Neuner, Ursula Jäkle, Elmar Schiebel

Abstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Review
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  12. Review
  13. Mechanisms underlying spindle assembly and robustness.Nature reviews. Molecular cell biology · 2023
    Review
  14. Augmin is a Ran-regulated spindle assembly factor.The Journal of biological chemistry · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. How Microtubules Build the Spindle Branch by Branch.Annual review of cell and developmental biology · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Judith GunzelmannZentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Allianz, Heidelberg, Germany.
Diana RüthnickZentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Allianz, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-6365-4050
Tien-Chen LinZentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Allianz, Heidelberg, Germany.
Wanlu ZhangZentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Allianz, Heidelberg, Germany.
Annett NeunerZentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Allianz, Heidelberg, Germany.
Ursula JäkleZentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Allianz, Heidelberg, Germany.
Elmar SchiebelZentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Allianz, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-3683-247X

Funding

Deutsche Forschungsgemeinschaft Schi295/4-3
6 · The paper itself

Abstract

Stu2/XMAP215/ZYG-9/Dis1/Alp14/Msps/ch-TOG family members in association with with γ-tubulin complexes nucleate microtubules, but we know little about the interplay of these nucleation factors. Here, we show that the budding yeast Stu2 in complex with the γ-tubulin receptor Spc72 nucleates microtubules in vitro without the small γ-tubulin complex (γ-TuSC). Upon γ-TuSC addition, Stu2 facilitates Spc72

Indexed as

Protein MultimerizationMicrotubule-Associated ProteinsMicrotubulesMutant ProteinsProtein BindingProtein DomainsProtein StabilitySaccharomyces cerevisiae ProteinsTubulinMicrotubule-Associated ProteinsMutant ProteinsSaccharomyces cerevisiae ProteinsSTU2 protein, S cerevisiaeTubulincell biologymicrotubule nucleationS. cerevisiaeStu2TOG domain proteinγ-TuSC

Identifiers

PMID30222109
PMCPMC6158006

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.