ArticleeLife2018
Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Pooled it
- Article
- Manipulation of Wnt Signaling Pathway during Peripheral Nerve Regeneration.Cellular and molecular neurobiology · 2026Article
- Article
- Netrin-1-engineered endothelial cell exosomes induce the formation of pre-regenerative niche to accelerate peripheral nerve repair.Science advances · 2024Article
- Remyelination in the Central Nervous System.Cold Spring Harbor perspectives in biology · 2024Review
- Myelination- and migration-associated genes are downregulated after phagocytosis in cultured oligodendrocyte precursor cells.Journal of neurochemistry · 2023Article
- Molecular and Regenerative Characterization of Repair and Non-repair Schwann Cells.Cellular and molecular neurobiology · 2023Article
- Schwann Cell Remyelination in the Multiple Sclerosis Central Nervous System.Laboratory investigation; a journal of technical methods and pathology · 2023Article
- Forced Remyelination Promotes Axon Regeneration in a Rat Model of Spinal Cord Injury.International journal of molecular sciences · 2022Article
- Four Seasons for Schwann Cell Biology, Revisiting Key Periods: Development, Homeostasis, Repair, and Aging.Biomolecules · 2021Review
- Review
- Myelin Repair: From Animal Models to Humans.Frontiers in cellular neuroscience · 2021Review
- Schwann cell remyelination of the central nervous system: why does it happen and what are the benefits?Open biology · 2021Review
- Review
- Transplantation of Skin Precursor-Derived Schwann Cells Yields Better Locomotor Outcomes and Reduces Bladder Pathology in Rats with Chronic Spinal Cord Injury.Stem cell reports · 2020Article
- Recent updates on mechanisms of cell-cell interaction in oligodendrocyte regeneration after white matter injury.Neuroscience letters · 2020Review
- Csf1 Deficiency Dysregulates Glial Responses to Demyelination and Disturbs CNS White Matter Remyelination.Cells · 2019Article
- Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling.Acta neuropathologica · 2019Article
- Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Following CNS demyelination, oligodendrocyte progenitor cells (OPCs) are able to differentiate into either remyelinating oligodendrocytes (OLs) or remyelinating Schwann cells (SCs). However, the signals that determine which type of remyelinating cell is generated and the underlying mechanisms involved have not been identified. Here, we show that distinctive microenvironments created in discrete niches within demyelinated white matter determine fate decisions of adult OPCs. By comparative transcriptome profiling we demonstrate that an ectopic, injury-induced perivascular niche is enriched with secreted ligands of the BMP and Wnt signalling pathways, produced by activated OPCs and endothelium, whereas reactive astrocyte within non-vascular area express the dual BMP/Wnt antagonist Sostdc1. The balance of BMP/Wnt signalling network is instructive for OPCs to undertake fate decision shortly after their activation: disruption of the OPCs homeostasis during demyelination results in BMP4 upregulation, which, in the absence of Socstdc1, favours SCs differentiation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.