ArticleCartilage2020
Extracellular Matrix Determines Biomechanical Properties of Chondrospheres during Their Maturation
Article in Cartilage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Role of Matrix-Associated Autologous Chondrocyte Implantation with Spheroids in the Treatment of Large Chondral Defects in the Knee: A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Stage-specific MSC spheroid fusion enables bottom-up formation of stage-defined hierarchical cartilage graft.Materials today. Bio · 2026Article
- Evaluation of Cartilage Repair After Implantation of Labeled Human Chondrocytes as Free Cells or Spheroids in Rabbit Knees.International journal of molecular sciences · 2026Article
- High-Content Analysis of 3D Chondrogenic Pellets Derived from Primary Cells In Vitro.Biomedicines · 2026Article
- Multicellular microtissues from fused ligament- and bone-cell spheroids relevant to enthesis repair.Materials today. Bio · 2026Article
- Cartilaginous microtissues exhibit extreme resilience under compression with size-dependent mechanical properties.Biomaterials · 2025Article
- Modern experimental methods for assessing the effectiveness of tissue-engineered products for hyaline cartilage regeneration.Frontiers in bioengineering and biotechnology · 2025Review
- Spheroids from Epithelial and Mesenchymal Cell Phenotypes as Building Blocks in Bioprinting (Review).Sovremennye tekhnologii v meditsine · 2025Review
- Analyzing force measurements of multi-cellular clusters comprising indeterminate geometries.Biomechanics and modeling in mechanobiology · 2024Article
- Bidirectionally validatedFrontiers in bioengineering and biotechnology · 2024Article
- Recent advances in soluble decellularized extracellular matrix for heart tissue engineering and organ modeling.Journal of biomaterials applications · 2023Review
- Articular Cartilage Regeneration through Bioassembling Spherical Micro-Cartilage Building Blocks.Cells · 2022Review
- Article
- A platform for automated and label-free monitoring of morphological features and kinetics of spheroid fusion.Frontiers in bioengineering and biotechnology · 2022Article
- Biocompatible micro tweezers for 3D hydrogel organoid array mechanical characterization.PloS one · 2022Article
- Hyaluronic AcidCartilage · 2021Article
- Mechanical properties of cell sheets and spheroids: the link between single cells and complex tissues.Biophysical reviews · 2021Review
- Studies of nanoparticle delivery withBioactive materials · 2020Review
- Cell spheroid fusion: beyond liquid drops model.Scientific reports · 2020Article
- Magnetic levitational bioassembly of 3D tissue construct in space.Science advances · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveChondrospheres represent a variant of tissue spheroids biofabricated from chondrocytes. They are already being used in clinical trials for cartilage repair; however, their biomechanical properties have not been systematically investigated yet. The aim of our study was to characterize chondrospheres in long-term
resultsIt has been demonstrated that the increase in chondrospheres secant modulus of elasticity is strongly associated with the synthesis and accumulation of extracellular matrix. Additionally, significant interplay has been found between biomechanical properties of tissue spheroids and their fusion kinetics in contrast to their spreading kinetics.
conclusionsExtracellular matrix is one of the main structural determinants of chondrospheres biomechanical properties during chondrogenic maturation
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.