ArticleJournal of the American Chemical Society2018
Molecular Recognition of Methionine-Terminated Peptides by Cucurbit[8]uril.
Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 89 citations in OpenAlex.
- Nanomolar Affinity Host-Dye Reporter Pairs from Fluorescently Labeled Oligoarginine Peptides and p-Sulfonatocalix[4]arene.Chembiochem : a European journal of chemical biology · 2026Article
- Embracing Complexity: Peptides as Tunable Scaffolds in the Construction of Discrete Supramolecular Systems.Angewandte Chemie (International ed. in English) · 2025Review
- Protein Recognition and Assembly by a Phosphocavitand.Journal of the American Chemical Society · 2025Article
- Modular protein frameworks via supramolecular synthons.Biophysical reviews · 2025Review
- N‑Terminal Protein Complexation and Assembly with a Triangular Sulfated Macrocycle.Crystal growth & design · 2025Article
- Making and Breaking Supramolecular Synthons for Modular Protein Frameworks.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Chiral ring-in-ring complexes with torsion-induced circularly polarized luminescence.Chemical science · 2025Article
- Synergy-Promoted Specific Alkyltriphenylphosphonium Binding to CB[8].The Journal of organic chemistry · 2025Article
- N-Terminal Protein Binding and Disorder-to-Order Transition by a Synthetic Receptor.Biochemistry · 2025Article
- Supramolecular nanotherapeutics based on cucurbiturils.Journal of nanobiotechnology · 2024Review
- Biomimetic Entropy-Dominant Molecular Hinges with Picomolar Affinity.Journal of the American Chemical Society · 2024Article
- Host-guest binding between cucurbit[8]uril and amphiphilic peptides achieved tunable supramolecular aggregates for cancer diagnosis.Chemical science · 2024Article
- Selective detection of paraquat by a cucurbit[7]uril-based fluorescent probe.Journal of pesticide science · 2024Article
- Peptide recognition by a synthetic receptor at subnanomolar concentrations.Chemical science · 2024Article
- Cucurbit[8]uril Binds Nonterminal Dipeptide Sites with High Affinity and Induces a Type II β-Turn.Journal of the American Chemical Society · 2024Article
- A Closed Cavity Strategy for Selective Dipeptide Binding by a Polyaromatic Receptor in Water.JACS Au · 2023Article
- Chiral adaptive recognition with sequence specificity of aromatic dipeptides in aqueous solution by an achiral cage.Chemical science · 2023Article
- Semisynthesis of Aminomethyl-Insulin: An Atom-Economic Strategy to Increase the Affinity and Selectivity of a Protein for Recognition by a Synthetic Receptor.Bioconjugate chemistry · 2023Article
- A fluorescent probe for detection of HgBeilstein journal of organic chemistry · 2023Article
- Cucurbit[Frontiers in chemistry · 2023Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
This Article describes the molecular recognition of peptides containing an N-terminal methionine (Met) by the synthetic receptor cucurbit[8]uril (Q8) in aqueous solution and with submicromolar affinity. Prior work established that Q8 binds with high affinity to peptides containing aromatic amino acids, either by simultaneous binding of two aromatic residues, one from each of two different peptides, or by simultaneous binding of an aromatic residue and its immediate neighbor on the same peptide. The additional binding interface of two neighboring residues suggested the possibility of targeting nonaromatic peptides, which have thus far bound only weakly to synthetic receptors. A peptide library designed to test this hypothesis was synthesized and screened qualitatively for Q8 binding using a fluorescent indicator displacement assay. The large fluorescence response observed for several Met-terminated peptides suggested strong binding, which was confirmed quantitatively by the determination of submicromolar equilibrium dissociation constant values for Q8 binding to MLA, MYA, and MFA using isothermal titration calorimetry (ITC). This discovery of high affinity binding to Met-terminated peptides and, more generally, to nonaromatic peptides prompted a detailed investigation of the determinants of binding in this system using ITC, electrospray ionization mass spectrometry, and
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.