ArticleVirulence2018
Streptococcus suis synthesizes deoxyadenosine and adenosine by 5'-nucleotidase to dampen host immune responses.
Article in Virulence, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- Pathogenicity and virulence ofVirulence · 2026Review
- Innate immune response to Streptococcus suis infection: advances and future challenges.Veterinary research · 2026Review
- Dead but not gone: the interplay between the programmed cell death process and surrounding bacteria.Infection and immunity · 2026Review
- Review
- HylS', a fragment of truncated hyaluronidase ofVirulence · 2024Article
- Article
- Targeting host deoxycytidine kinase mitigateseLife · 2024Article
- Comparative Genome Analysis of TwoAnimals : an open access journal from MDPI · 2024Article
- Neutrophil extracellular traps in bacterial infections and evasion strategies.Frontiers in immunology · 2024Review
- Suppression of certain intestinal microbiota metabolites may lead to gestational diabetes in mice fed a high-fat diet.Frontiers in microbiology · 2024Article
- A novel aquaporin Aagp contributes toVirulence · 2023Article
- Pathogen-driven nucleotide overload triggers mitochondria-centered cell death in phagocytes.PLoS pathogens · 2023Article
- Article
- Immune Memory After Respiratory Infection WithFrontiers in cellular and infection microbiology · 2022Article
- Article
- Neutrophils inMicroorganisms · 2021Review
- Serotypes, Virulence-Associated Factors, and Antimicrobial Resistance ofFrontiers in veterinary science · 2021Article
- YSIRK-G/S-directed translocation is required forVirulence · 2020Article
- Functional Analysis of Two NovelMicroorganisms · 2020Article
- Streptococcus suis Serotype 2 Infection Causes Host Immunomodulation through Induction of Thymic Atrophy.Infection and immunity · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus suis is a major porcine bacterial pathogen and emerging zoonotic agent. S. suis 5'-nucleotidase is able to convert adenosine monophosphate to adenosine, resulting in inhibiting neutrophil functions in vitro and it is an important virulence factor. Here, we show that S. suis 5'-nucleotidase not only enables producing 2'-deoxyadenosine from 2'-deoxyadenosine monophosphate by the enzymatic assay and reversed-phase high performance liquid chromatography (RP-HPLC) analysis in vitro, but also synthesizes both 2'-deoxyadenosine and adenosine in mouse blood in vivo by RP-HPLC and liquid chromatography with tandem mass spectrometry analyses. Cellular cytotoxicity assay and Western blot analysis indicated that the production of 2'-deoxyadenosine by 5'-nucleotidase triggered the death of mouse macrophages RAW 264.7 in a caspase-3-dependent way. The in vivo infection experiment showed that 2'-deoxyadenosine synthesized by 5'-nucleotidase caused monocytopenia in mouse blood. The in vivo transcriptome analysis in mouse blood showed the inhibitory effect of 5'-nucleotidase on neutrophil functions and immune responses probably mediated through the generation of adenosine. Taken together, these findings indicate that S. suis synthesizes 2'-deoxyadenosine and adenosine by 5'-nucleotidase to dampen host immune responses, which represents a new mechanism of S. suis pathogenesis.
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