Evidence map›Paper›PMID 30221478›Full record

ArticleJournal of cachexia, sarcopenia and muscle2018

The prevalence of sarcopenia and relationships between muscle and bone in ageing West-African Gambian men and women.

Ayse Zengin, Landing M Jarjou, Ann Prentice, Cyrus Cooper, Peter R Ebeling, Kate A Ward

Open access · goldAbstract read
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Prevalence of Sarcopenia in Africa: A Systematic Review.Clinical interventions in aging · 2023
    Pooled it
  3. Pooled it
  4. Rural-urban differences in osteoporosis and sarcopenia prevalence among Gambian older adults: a pilot study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Vertebral fracture prevalence and risk factors for fracture in The Gambia, West Africa: the Gambian Bone and Muscle Ageing Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Observational
  9. Review
  10. Article
  11. Article
  12. Ethical considerations in sarcopenia research.Journal of medical ethics and history of medicine · 2023
    Article
  13. Article
  14. Is age-related sarcopenia a real concern for my developing country?Journal of cachexia, sarcopenia and muscle · 2022
    Article
  15. Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Ayse ZenginDepartment of Medicine, School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Monash Medical Centre, Clayton, VIC, Australia.ORCID 0000-0001-6428-6165
Landing M JarjouMRC Unit The Gambia, Keneba, The Gambia.
Ann PrenticeMRC Elsie Widdowson Laboratory, Cambridge, UK.ORCID 0000-0003-0254-6659
Cyrus CooperMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.ORCID 0000-0003-3510-0709
Peter R EbelingDepartment of Medicine, School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Monash Medical Centre, Clayton, VIC, Australia.
Kate A WardMRC Elsie Widdowson Laboratory, Cambridge, UK.ORCID 0000-0001-7034-6750
MRC Human Nutrition Research · GBMonash Medical Centre · AUMRC Unit the Gambia · GMNational Institute for Health Research · GB

Funding

Department of Health 10/33/04Medical Research Council G0400491Medical Research Council G0601019Medical Research Council MC_U105960371Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UP_A620_1015Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12011/2Medical Research Council U123261351
6 · The paper itself

Abstract

backgroundThe rapidly rising ageing population in low and middle-income countries (LMIC) will lead to a concurrent increase in musculoskeletal diseases. Sarcopenia is a disease caused by progressive loss of skeletal muscle mass and strength, leading to adverse outcomes including frailty, falls, fractures, and premature mortality. We investigated the prevalence of sarcopenia, assessed the suitability of current diagnostic guidelines and explored muscle-bone relationships in ageing men and women from rural Gambia.

methodsA total of 249 women and 239 men aged 40-75+ years were recruited. Body composition was measured using dual energy X-ray absorptiometry. Comparisons of the Foundations for the National Institutes of Health (FNIH) and European Working Group On Sarcopenia (EWGSOP) definitions of sarcopenia to define prevalence and to identify poor physical capability were determined. Functional ability was assessed by jumping mechanography to calculate lower limb muscle force and power; grip strength was assessed by a hand dynamometer. Peripheral quantitative computed tomography was used to assess muscle-bone relationships.

resultsThe prevalence of sarcopenia in Gambian men and women significantly varied depending on the definition used; in men 20% and 19% and in women 45% and 10% for FNIH and EWGSOP, respectively. The FNIH appendicular lean mass cut-off had greatest sensitivity and specificity in identifying low functional ability in Gambian adults. Muscle force was positively associated with measures of tibial bone size, strength, and mineral content.

conclusionsThe variation in the prevalence of sarcopenia depends on the definition used and highlights the importance of measuring functional capability across ethnic populations.

Indexed as

Absorptiometry, PhotonAdultAgedAged, 80 and overAgingBody CompositionBone and BonesFemaleGambiaGeriatric AssessmentHumansMaleMiddle AgedMuscle, SkeletalMuscle StrengthPrevalenceAgeingBoneEthnicityJumping mechanographyMuscleSarcopenia

Identifiers

PMID30221478
PMCPMC6204597
OpenAlexW2891900394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.