Evidence map›Paper›PMID 30221332›Full record

ReviewCurrent psychiatry reports2018

Examining the Relationship Between Neurosteroids, Cognition, and Menopause With Neuroimaging Methods.

Baillie Frizell, Julie A Dumas

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current psychiatry reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Gonadal hormone abnormalities in young patients with first-episode schizophrenia.The international journal of neuropsychopharmacology · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Baillie FrizellClinical Neuroscience Research Unit, Department of Psychiatry, Robert Larner M.D. College of Medicine, University of Vermont, 1 South Prospect St, Burlington, VT, 05401, USA.
Julie A DumasClinical Neuroscience Research Unit, Department of Psychiatry, Robert Larner M.D. College of Medicine, University of Vermont, 1 South Prospect St, Burlington, VT, 05401, USA. Julie.Dumas@uvm.edu.
University of Vermont · US

Funding

The Nicotinic Cholinergic System and Cognitive AgingR01AG050716 · NIA · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI DUMAS, JULIE A · 2016 to 2020
$2.1M
Summer Research Experience in Neuroscience for UndergraduatesR25NS090623 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SCOTT, RODNEY CRAIG · 2014 to 2018
$222k
NIA NIH HHS R01 AG050716NINDS NIH HHS R25 NS090623
6 · The paper itself

Abstract

purpose of reviewPrevious literature has shown inconsistent findings regarding the effects of neurosteroids on the brain in postmenopausal women. The goal of this paper is to examine how and whether advances in neuroimaging have helped elucidate the relationship between the withdrawal of and/or treatment with neurosteroids and cognition at menopause. RECENT

findingsNeuroimaging techniques such as structural and functional MRI have been used in recent studies to examine the relationship between neurosteroids and brain structure and functioning. However, the recent literature shows that different formulations of postmenopausal hormones given at different times, through different routes of administration, and in different combinations with progestins result in a variety of relationships with the brain outcomes. We suggest that still further research is needed to understand how the structural changes resulting from estrogen withdrawal or therapy at menopause can influence cognitive functioning. However, imaging studies are time-, resource-, and expertise-intensive. We believe that this information will help uncover the mechanisms and relationships that can aid in the explanation of the individual differences in the effects of menopause on the brain as well as how this menopause-related hormone change influences risk for pathological aging.

Indexed as

NeuroimagingBrainCognitionEstrogensFemaleHumansMenopauseNeurotransmitter AgentsProgestinsEstrogensNeurotransmitter AgentsProgestinsCognitionEstrogenHormone therapyMenopauseNeuroimaging

Identifiers

PMID30221332
OpenAlexW2890499160

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.