Evidence map›Paper›PMID 30221330›Full record

Trial reportEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2019

Similar thromboprophylaxis with rivaroxaban and low molecular weight heparin but fewer hemorrhagic complications with combined intra-articular and intravenous tranexamic acid in total knee arthroplasty.

Panayiotis K Karampinas, Panayiotis D Megaloikonomos, Kalliopi Lampropoulou-Adamidou, Eleftherios G Papadelis, Andreas F Mavrogenis, John A Vlamis, Spyros G Pneumaticos

Abstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Observational
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Panayiotis K KarampinasThird Departments of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
Panayiotis D MegaloikonomosFirst Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, 41 Ventouri Street, Holargos, 15562, Athens, Greece.
Kalliopi Lampropoulou-AdamidouThird Departments of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
Eleftherios G PapadelisThird Departments of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
Andreas F MavrogenisFirst Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, 41 Ventouri Street, Holargos, 15562, Athens, Greece. afm@otenet.gr.
John A VlamisThird Departments of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
Spyros G PneumaticosThird Departments of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the efficacy of the combined intravenous and intra-articular administration of tranexamic acid (TXA) to control the collateral effects and complications of rivaroxaban (RIV) after total knee arthroplasty (TKA) and to compare thromboprophylaxis schemes with and without TXA, RIV and low molecular weight heparin (LMWH). MATERIALS AND

methodsWe prospectively studied 158 TKA patients from 2014 to 2018. The patients were randomly assigned into three groups. Group A (46 patients) was administered intravenous and intra-articular TXA and RIV postoperatively; group B (58 patients) was administered TXA as in group A and LMWH postoperatively; and group C (54 patients) was administered saline as in group A and RIV postoperatively. We evaluated blood loss, transfusion requirements and hemorrhagic complications.

resultsHct and Hb values significantly decreased in group C compared to groups A and B, without any difference between groups A and B. Suction drain blood volume output was significantly higher in group C compared to group A and B, without any difference between group A and B. Hemorrhagic complications were more common in group C. No patient experienced clinical findings of VTE.

conclusionCombined intravenous and intra-articular administration of TXA is safe and effective in TKA, with fewer hemorrhagic complications compared to placebo. Thromboprophylaxis with RIV and LMWH is similar.

Indexed as

AdultAgedAged, 80 and overAnticoagulantsArthroplasty, Replacement, KneeBlood Loss, SurgicalBlood TransfusionDrug Therapy, CombinationFemaleHeparin, Low-Molecular-WeightHumansInfusions, IntravenousInjections, Intra-ArticularMaleMiddle AgedPostoperative HemorrhageAnticoagulantsHeparin, Low-Molecular-WeightRivaroxabanTranexamic AcidBlood lossRivaroxabanThromboprophylaxisTotal knee arthroplastyTranexamic acidTransfusion

Identifiers

PMID30221330

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.