Evidence map›Paper›PMID 30221238›Full record

ArticleACS omega2018

Protein Fibril-Templated Biomimetic Synthesis of Highly Fluorescent Gold Nanoclusters and Their Applications in Cysteine Sensing.

Indrani Nandi, Sayantani Chall, Sourav Chowdhury, Tulika Mitra, Sib Sankar Roy, Krishnananda Chattopadhyay

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
  2. Tripeptide-Assisted Gold Nanocluster Formation for FeMolecules (Basel, Switzerland) · 2024
    Article
  3. Article
  4. Aggregation-caused dual-signal response of gold nanoclusters for ratiometric optical detection of cysteine.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Self-Assembly of Metal Nanoclusters for Aggregation-Induced Emission.International journal of molecular sciences · 2019
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Indrani NandiProtein Folding and Dynamics Laboratory, Structural Biology & Bio-Informatics Division, and Metabolic Disorder Laboratory, Cell Biology and Physiology Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata 700032, India.
Sayantani ChallProtein Folding and Dynamics Laboratory, Structural Biology & Bio-Informatics Division, and Metabolic Disorder Laboratory, Cell Biology and Physiology Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata 700032, India.
Sourav ChowdhuryProtein Folding and Dynamics Laboratory, Structural Biology & Bio-Informatics Division, and Metabolic Disorder Laboratory, Cell Biology and Physiology Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata 700032, India.
Tulika MitraProtein Folding and Dynamics Laboratory, Structural Biology & Bio-Informatics Division, and Metabolic Disorder Laboratory, Cell Biology and Physiology Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata 700032, India.
Sib Sankar RoyProtein Folding and Dynamics Laboratory, Structural Biology & Bio-Informatics Division, and Metabolic Disorder Laboratory, Cell Biology and Physiology Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata 700032, India.
Krishnananda ChattopadhyayProtein Folding and Dynamics Laboratory, Structural Biology & Bio-Informatics Division, and Metabolic Disorder Laboratory, Cell Biology and Physiology Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata 700032, India.
Indian Institute of Chemical Biology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomimetic synthesis of multifunctional fluorescent gold nanoclusters (Au NCs) is of great demand because of their ever-increasing applications. In this study, we have used self-assembled bovine serum albumin (BSA) amyloid-like nanofibers as the bioinspired scaffold for the synthesis of Au NCs. The amyloid fibril stabilized gold nanocluster (Fib-Au NC) has been found to have appreciable enhancement of fluorescence emission and a large 25 nm red shift in its emission maxima when compared to its monomeric protein counterpart (BSA-Au NC). The underlying mechanism accountable for the fluorescence behavior and its spectral shift has been thoroughly investigated by a combined use of spectroscopic and microscopic techniques. We have subsequently demonstrated the use of Fib-Au NCs for cysteine (Cys) sensing both in vitro and inside live cells. Additionally, cellular uptake and postpermeation effect of Fib-Au NCs have also been ascertained by detailed flow cytometry analysis, viability assay, and real-time apoptotic gene expression profiling.

Identifiers

PMID30221238
PMCPMC6130899
OpenAlexW2845050813

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.