ArticleCurrent opinion in behavioral sciences2018
Sex Differences and the Effects of Estradiol on Striatal Function.
Article in Current opinion in behavioral sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 58 citations in OpenAlex.
- Proteomic Characterization of Striatal Neurabin Interactome and Its Sex Specific Impact on Motor Behavior.ACS chemical neuroscience · 2026Article
- Castration-induced nigrostriatal deficits are linked to reduced TrkB and loss of mature spines in the dorsal striatum.Frontiers in endocrinology · 2026Article
- Proteomic Characterization of Striatal Neurabin Interactome and its Sex Specific Impact on Motor Behavior.bioRxiv : the preprint server for biology · 2025Article
- Neuron soma size and density measurements in rat striatal regions disaggregated by sex and estrous cycle phase.Brain structure & function · 2025Article
- Sex Differences in the Striatal Contributions to Longitudinal Fine Motor Development in Autistic Children.Biological psychiatry · 2025Article
- Estradiol protects against pain-facilitated fentanyl use via suppression of opioid-evoked dopamine activity in males.Neuron · 2025Article
- Sexual Dimorphism in Levodopa-Induced Dyskinesia Following Parkinson's Disease: Uncharted Territory.The European journal of neuroscience · 2025Review
- A review of the effects of different types of social behaviors on the recruitment of neuropeptides and neurotransmitters in the nucleus accumbens.Frontiers in neuroendocrinology · 2025Review
- Fetal endocrine axes mRNA expression levels are related to sex and intrauterine position.Biology of sex differences · 2024Article
- Sex mechanisms as nonbinary influences on cognitive diversity.Hormones and behavior · 2024Review
- Fundamental Sex Differences in Cocaine-Induced Plasticity of Dopamine D1 Receptor- and D2 Receptor-Expressing Medium Spiny Neurons in the Mouse Nucleus Accumbens Shell.Biological psychiatry global open science · 2024Article
- Review
- Sex differences in pre- and post-synaptic glutamate signaling in the nucleus accumbens core.Biology of sex differences · 2023Article
- Article
- Estrous cycle impacts on dendritic spine plasticity in rat nucleus accumbens core and shell and caudate-putamen.The Journal of comparative neurology · 2023Article
- Male and female C57BL/6 mice display drug-induced aversion and reward in the combined conditioned taste avoidance/conditioned place preference procedure.Pharmacology, biochemistry, and behavior · 2023Article
- Emerging Evidence on Membrane Estrogen Receptors as Novel Therapeutic Targets for Central Nervous System Pathologies.International journal of molecular sciences · 2023Review
- Excessive self-grooming, gene dysregulation and imbalance between the striosome and matrix compartments in the striatum ofFrontiers in molecular neuroscience · 2023Article
- ERα Stimulation Rapidly Modulates Excitatory Synapse Properties in Female Rat Nucleus Accumbens Core.Neuroendocrinology · 2023Article
- Methylone pre-exposure differentially impacts the aversive effects of MDPV and MDMA in male and female Sprague-Dawley rats: Implications for abuse vulnerability.Pharmacology, biochemistry, and behavior · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The striatal brain regions, including the caudate-putamen, nucleus accumbens core, and nucleus accumbens shell, mediate critical behavioral functions. These functions include but are not limited to motivated behavior, reward, learning, and sensorimotor function in both pathological and normal contexts. The phenotype and/or incidence of all of these behaviors either differ by sex or are sensitive to the presence of gonadal hormones such as 17β-estradiol and testosterone. All three striatal brain regions express membrane-associated estrogen receptors. Here we present a brief review of the recent literature reporting on sex differences and effects of the estrogenic hormone 17β-estradiol on behavioral and neural function across all three striatal regions, focusing upon the most prominent striatal neuron type, the medium spiny neuron. We emphasize recent findings in three broad domains: (1) select striatal-relevant behaviors and disorders, (2) striatal medium spiny neuron dendritic spine density, and (3), striatal medium spiny neuron electrophysiological properties including excitatory synaptic input and intrinsic cellular excitability. These recent advances in behavior, neuroanatomy, and electrophysiology collectively offer insight into the effects of sex and estrogen on striatal function, especially at the level of individual neurons.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.