ArticleJournal of microscopy and ultrastructure
Histological Effects of Gold Nanoparticles on the Lung Tissue of Adult Male Albino Rats.
Article in Journal of microscopy and ultrastructure. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 16 citations in OpenAlex.
- Assessing the toxicity of one-step-synthesized PEG-coated gold nanoparticles: in vitro and in vivo studies.Einstein (Sao Paulo, Brazil) · 2024Article
- Mechanisms of cell injury induced by inhaled molybdenum trioxide nanoparticles in Golden Syrian Hamsters.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Gold nanomaterials in the management of lung cancer.Emerging topics in life sciences · 2020Review
- Histological Assessment of Systemic Toxicity Induced by Zinc oxide Nanoparticles and the Prophylactic Potency of Ascorbate in Albino Rats.Journal of microscopy and ultrastructureArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SHORT
introductionNanoparticles (NPs) represent a new line in the investigations and treatment of group of diseases. Furthermore, it is found in many products and enters the body by different roots as ingestion and inhalation. Lung is more liable to exposure to these particles. Safety of these particles on the lung needs to be examined. AIM OF THE WORK: To study the effect of gold NPs (GNPs) on the histological structure of the lung tissue. MATERIALS AND
methodsThirty-six healthy male albino rats were randomly divided into three groups including control group (Group I) and two GNP-treated groups (Group II received low dose and Group III received high dose daily for 14 days). At the end of the experiment, all the rats were sacrificed; lungs were dissected and processed to be examined by light and electron microscopy.
resultsGNPs induced inflammatory infiltration dilatation and congestion of the blood vessels in association with the collapse of lung alveoli and extravasations of red blood cells. Caspase-3 immunohistochemical reaction showed strong positive reaction in Group III mainly. Ultrastructure observation revealed affection of type II pneumocyte and thickening in the alveolar wall.
conclusionsGNPs led to histological changes in the lung tissue.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.