Evidence map›Paper›PMID 30221017›Full record

ArticleLiver research (Beijing, China)2018

Levels of circulating follicular helper T cells, T helper 1 cells, and the prognostic significance of soluble form of CD40 ligand on survival in patients with alcoholic cirrhosis.

Kristin Hollister, Praveen Kusumanchi, Ruth Ann Ross, Kristina Chandler, AdePeju Oshodi, Laura Heathers, Sean Teagarden, Li Wang, Alexander L Dent, Suthat Liangpunsakul

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Liver research (Beijing, China), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Kristin HollisterDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Praveen KusumanchiDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Ruth Ann RossDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Kristina ChandlerDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
AdePeju OshodiDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Laura HeathersDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Sean TeagardenDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Li WangDepartment of Physiology and Neurobiology, and the Institute for Systems Genomics, University of Connecticut, Storrs, CT, USA.
Alexander L DentDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Suthat LiangpunsakulDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Indiana University – Purdue University Indianapolis · USIndiana University School of MedicineWenzhou Medical University · CN

Funding

Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI MICHAEL H NATHANSON · 1986 to 2026
$31.1M
Translational Research and Evolving Alcoholic hepatitis Treatment (TREAT-IU)U01AA021840 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI NAGA P CHALASANI, Olawale Ojo · 2012 to 2026
$8.1M
Genetic risk factors for alcoholic cirrhosis - genome-wide case-control studyU01AA018389 · NIAAA · SOUTHERN CALIFORNIA INST FOR RES/EDUC · PI CORDELL, HEATHER JANE, DALY, ANN · 2011 to 2018
$3.0M
SHP-regulation of Lipid and Lipoprotein MetabolismR01DK080440 · NIDDK · UNIVERSITY OF UTAH · PI WANG, LI · 2008 to 2015
$2.3M
Novel biomarkers as a clinical tool for excessive alcohol use screeningR01AA025208 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LIANGPUNSAKUL, SUTHAT, TU, WANZHU · 2016 to 2020
$1.7M
LncRNA as a New Mediator of Bile Acid HomeostasisR01DK104656 · NIDDK · UNIVERSITY OF CONNECTICUT STORRS · PI WANG, LI · 2015 to 2018
$1.7M
Sestrin3 in the pathogenesis of alcoholic and non-alcoholic fatty liver diseaseR01DK107682 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DONG, X. CHARLIE, LIANGPUNSAKUL, SUTHAT · 2016 to 2019
$1.4M
Molecular Basis of Cancer Cell Metabolic ReprogrammingR01ES025909 · NIEHS · UNIVERSITY OF CONNECTICUT STORRS · PI WANG, LI · 2015 to 2017
$1.0M
Effect of ethanol on Kupffer cell/hepatocyte interactions and lipid metabolismK08AA016570 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LIANGPUNSAKUL, SUTHAT · 2008 to 2012
$659k
The Role of Follicular Helper T Cells in HIV Prime Boost VaccinationR56AI112398 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI DENT, ALEXANDER L · 2014 to 2014
$603k
Long noncoding RNAs in alcoholic liver diseaseR21AA024935 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LIANGPUNSAKUL, SUTHAT, WANG, LI · 2016 to 2017
$431k
Alcohol, nuclear receptor signaling, and circadian clocksR21AA022482 · NIAAA · UNIVERSITY OF CONNECTICUT STORRS · PI WANG, LI · 2015 to 2016
$415k
BLRD VA I01 BX002634CSRD VA I01 CX000361NCI NIH HHS R21 CA191507NIAAA NIH HHS K08 AA016570NIAAA NIH HHS R01 AA025208NIAAA NIH HHS R21 AA022482NIAAA NIH HHS R21 AA024935NIAAA NIH HHS U01 AA018389NIAAA NIH HHS U01 AA021840NIAID NIH HHS R03 AI110987NIAID NIH HHS R56 AI112398NIDDK NIH HHS P30 DK034989NIDDK NIH HHS R01 DK080440NIDDK NIH HHS R01 DK104656NIDDK NIH HHS R01 DK107682NIEHS NIH HHS R01 ES025909
6 · The paper itself

Abstract

backgroundExcessive drinkers (ED) and patients with alcoholic liver disease (ALD) are several times more susceptible to bacterial and viral infections and have a decrease in antibody responses to vaccinations. Follicular helper T (TFH) cells are essential to select B cells in the germinal center and to produce antibodies. TFH cells express both a membrane-associated and a soluble form of CD40 ligand (sCD40L); in which the latter form is released to circulation upon T cell activation. The effect of alcohol on TFH cells has not been studied.

objectivesThe goals of this study are to determine the levels of TFH and T helper 1 (Th1) cells in ED and those with alcoholic cirrhosis (AC) when compared to healthy controls and to determine the prognostic significance of sCD40L in a cohort of patients with AC.

methodsControls, ED, and those with AC were enrolled. Baseline demographic, laboratory tests, and peripheral blood mononuclear cells (PBMCs) were isolated and assessed via flow cytometry for TFH cells.

resultsThe levels of circulating TFH (cTFH) cells were significantly lower in peripheral blood of subjects with ED and AC compared to controls (

conclusionsPatients with AC had significantly lower level of cTFH and sCD40L. The level of sCD40L was an independent predictor of mortality in these patients.

Indexed as

Alcoholic cirrhosis (AC)Alcoholic liver disease (ALD)Circulating follicular helper T (cTFH) cellsFollicular helper T (TFH) cellsSoluble form of CD40 ligand (sCD40L)T helper 1 (Th1)

Identifiers

PMID30221017
PMCPMC6136446
OpenAlexW2791969524

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.