Evidence map›Paper›PMID 30220999›Full record

ArticleAntimicrobial resistance and infection control2018

Predictive factors for multidrug-resistant gram-negative bacteria among hospitalised patients with complicated urinary tract infections.

Aina Gomila, Evelyn Shaw, Jordi Carratalà, Leonard Leibovici, Cristian Tebé, Irith Wiegand, Laura Vallejo-Torres, Joan M Vigo, Stephen Morris, Margaret Stoddart and 10 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Antimicrobial resistance and infection control, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 71 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 5 countries.

Aina Gomila1Department of Infectious Diseases, Hospital Universitari de Bellvitge, Institut Català de la Salut (ICS-HUB), Feixa Llarga s/n, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.ORCID 0000-0001-6979-9269
Evelyn Shaw1Department of Infectious Diseases, Hospital Universitari de Bellvitge, Institut Català de la Salut (ICS-HUB), Feixa Llarga s/n, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
Jordi Carratalà1Department of Infectious Diseases, Hospital Universitari de Bellvitge, Institut Català de la Salut (ICS-HUB), Feixa Llarga s/n, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
Leonard Leibovici5Department of Medicine E, Beilinson Hospital, Rabin Medical Center, Petah Tikva; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Cristian Tebé3Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Feixa Llarga s/n, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
Irith WiegandAiCuris Anti-infective Cures GmbH, Wuppertal, Germany.
Laura Vallejo-Torres7UCL Department of Applied Health Research, University College London, London, UK.
Joan M Vigo8Informatics Unit, Fundació Institut Català de Farmacologia, Barcelona, Spain.
Stephen Morris7UCL Department of Applied Health Research, University College London, London, UK.
Margaret Stoddart9Department of Medical Microbiology, Southmead Hospital, North Bristol NHS Trust, Bristol, UK.
Sally Grier9Department of Medical Microbiology, Southmead Hospital, North Bristol NHS Trust, Bristol, UK.
Christiane VankAiCuris Anti-infective Cures GmbH, Wuppertal, Germany.
Nienke Cuperus10Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.
Leonard Van den Heuvel10Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.
Noa Eliakim-Raz5Department of Medicine E, Beilinson Hospital, Rabin Medical Center, Petah Tikva; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Cuong VuongAiCuris Anti-infective Cures GmbH, Wuppertal, Germany.
Alasdair MacGowan9Department of Medical Microbiology, Southmead Hospital, North Bristol NHS Trust, Bristol, UK.
Ibironke AddyAiCuris Anti-infective Cures GmbH, Wuppertal, Germany.
Miquel Pujol1Department of Infectious Diseases, Hospital Universitari de Bellvitge, Institut Català de la Salut (ICS-HUB), Feixa Llarga s/n, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
COMBACTE-MAGNET WP5- RESCUING Study
AiCuris (Germany) · DEInstituto de Salud Carlos III · ESNorth Bristol NHS Trust · GBTel Aviv University · ILUniversity College London · GBUniversity Medical Center Utrecht · NLInstitut d'Investigació Biomédica de Bellvitge · ESSociedad Española de Farmacología Clínica · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patients with complicated urinary tract infections (cUTIs) frequently receive broad-spectrum antibiotics. We aimed to determine the prevalence and predictive factors of multidrug-resistant gram-negative bacteria in patients with cUTI. Methods: This is a multicenter, retrospective cohort study in south and eastern Europe, Turkey and Israel including consecutive patients with cUTIs hospitalised between January 2013 and December 2014. Multidrug-resistance was defined as non-susceptibility to at least one agent in three or more antimicrobial categories. A mixed-effects logistic regression model was used to determine predictive factors of multidrug-resistant gram-negative bacteria cUTI. Results: From 948 patients and 1074 microbiological isolates, Conclusions: The current high rate of multidrug-resistant gram-negative bacteria infections among hospitalised patients with cUTIs in the studied area is alarming. Our predictive model could be useful to avoid inappropriate antibiotic treatment and implement antibiotic stewardship policies that enhance the use of carbapenem-sparing regimens in patients at low risk of multidrug-resistance.

Indexed as

Cross InfectionDrug Resistance, Multiple, BacterialAgedAged, 80 and overAnti-Bacterial AgentsFemaleGram-Negative BacteriaGram-Negative Bacterial InfectionsHospitalizationHumansMaleMiddle AgedOdds RatioRetrospective StudiesROC CurveUrinary Tract InfectionsAnti-Bacterial AgentsComplicated urinary tract infectionGram-negative bacteriaMultidrug-resistancePredictive model of multidrug-resistance gram-negative bacteria

Identifiers

PMID30220999
PMCPMC6137881
OpenAlexW2891976312

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.