ArticlePathobiology of aging & age related diseases2018
Evaluation of aging, diabetes mellitus, and skin wounds by scanning acoustic microscopy with protease digestion.
Article in Pathobiology of aging & age related diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 15 citations in OpenAlex.
- Selective deletion or preservation of tissue components via enzymatic digestion monitored by scanning acoustic microscopy.Scientific reports · 2025Article
- Multimodal Second-Harmonic-Generation, Two-Photon Excitation Fluorescence, and Brillouin Microscopy for Visualising Dermal Mechanical Properties in Ex Vivo Human Skin.Experimental dermatology · 2025Article
- Stiffness reduction and collagenase resistance of aging lungs measured using scanning acoustic microscopy.PloS one · 2022Article
- Scanning acoustic microscopy imaging of cellular structural and mechanical alterations from external stimuli.Heliyon · 2021Article
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2 authors at 1 institution in 1 country.
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Abstract
Scanning acoustic microscopy (SAM) can assess tissue stiffness by calculating the speed of sound (SOS) through tissues. SOS increases as tissue stiffness increases. Sensitivity to protease digestion depends on protein type, concentration, and modification. We analyzed the SOS images of formalin-fixed paraffin-embedded skin sections from elderly, young, diabetic, and nondiabetic subjects, as well as chronic and acute wounds. SAM provided high-resolution histology similar to LM and revealed characteristic SOS alteration following pepsin treatment. SOS values of dermis samples from elderly subjects (especially females) were lower than those of younger adults, which was indicative of age-related dermal softening and loosening. SOS values of elderly females were lower than those of younger females and elderly males. Dermal SOS showed a positive correlation with epidermal thickness. SOS values of epidermis of elderly subjects were higher than those of younger adults and showed a rapid decline 0.5h after protease digestion. Reticular dermis of diabetic patients exhibited greater pepsin resistance than that of nondiabetic patients. Chronic wounds exhibited greater SOS values and pepsin resistance than acute wounds. SOS variation with aging, diabetes mellitus, and wound fibrosis reflected histological and mechanical changes associated with senescence and disease duration. Epidermal thickness reflects age-related changes in dermal stiffness.
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