Evidence map›Paper›PMID 30220946›Full record

ArticleWorld journal of oncology2018

Age-Related Chromosomal Aberrations in Patients with Diffuse Large B-Cell Lymphoma: An

Eric J Vick, Noah Richardson, Kruti Patel, Glenda M Delgado Ramos, Alaa Altahan, Taylor Alloway, Michael G Martin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eric J VickDepartment of Internal Medicine, University of Cincinnati, Cincinnati OH, USA.
Noah RichardsonCollege of Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA.
Kruti PatelDepartment of Internal Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA.
Glenda M Delgado RamosDepartment of Internal Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA.
Alaa AltahanDepartment of Internal Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA.
Taylor AllowayDepartment of Internal Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA.
Michael G MartinDepartment of Hematology and Oncology, The West Cancer Center, Memphis, TN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In diffuse large B-cell lymphoma (DLBCL), chromosomal aberrations are known to increase with advancing age. Our study aims to determine if there are other genetic aberrations associated with DLBCL based on age. Methods: Using the Mitelman Database of Genetic Aberrations, we were able to find 749 cases of DLBCL with genomic aberrations with a median age of 62 years. Patients with DLBCL chromosomal aberration analysis results were divided into four groups based on age (0 - 30, 31 - 50, 51 - 70, > 71 years) and examined by chi-square analysis and Mantel-Cox for survival analysis. Results: Ten aberrations were found to be significant with a particular age range: t(2;3), trisomy 19p13, trisomy 18q21, trisomy 3, trisomy 7, trisomy 14, trisomy 16, trisomy 18, monosomy 3 and monosomy 11, and survival ranged from 7 to 25 months. Conclusion: This suggests that patients with DLBCL are likely to accumulate specific translocations depending on their age at the onset of DLBCL.

Indexed as

Cancer and agingDiffuse large B-cell LymphomaGenetic aberrations

Identifiers

PMID30220946
PMCPMC6134989

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.