Evidence map›Paper›PMID 30220774›Full record

ArticleColloid and polymer science2017

Effects of Fluorosurfactant Structure and Concentration on Drug Availability and Biocompatibility in Water-in-Perfluorocarbon Emulsions for Pulmonary Drug Delivery.

Ryan A Orizondo, Diane L Nelson, Mario L Fabiilli, Keith E Cook

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Colloid and polymer science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ryan A OrizondoDepartment of Biomedical Engineering, University of Michigan, 1101 Beal Ave, Ann Arbor, MI 48109, United States.
Diane L NelsonDepartment of Biomedical Engineering, Carnegie Mellon University, 500 Forbes Ave, Pittsburgh, PA 15213, United States.
Mario L FabiilliDepartment of Radiology, University of Michigan, 1301 Catherine St, Ann Arbor, MI 48109, United States.
Keith E CookDepartment of Biomedical Engineering, Carnegie Mellon University, 500 Forbes Ave, Pittsburgh, PA 15213, United States.
Carnegie Mellon University · USUniversity of Michigan–Ann Arbor · US

Funding

Antibacterial Perfluorocarbon Ventilation to Treat Severe Respiratory InfectionsR03AI096029 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COOK, KEITH E · 2012 to 2013
$156k
NIAID NIH HHS R03 AI096029
6 · The paper itself

Abstract

The efficacy of inhaled antibiotics is often impaired by insufficient drug penetration into plugged and poorly ventilated airways. Liquid ventilation with perfluorocarbon (PFC) containing emulsified aqueous antibiotics, or antibacterial perfluorocarbon ventilation, could potentially improve treatment of respiratory infections when used as an adjunct therapy to inhaled antibiotics. The molecular structure and concentration of the fluorosurfactant used to stabilize such water-in-PFC emulsions will have significant effects on the efficacy and safety of the resulting treatment. In the present study, emulsions are formulated with tobramycin in the aqueous phase using two different fluorosurfactants (termed FSL-PEG+FSL and FSH-PEG) at varying concentrations (

Indexed as

emulsionfluorosurfactantperfluorocarbonpulmonary drug delivery

Identifiers

PMID30220774
PMCPMC6133303
OpenAlexW2770544118

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.