ArticleCurrent biology : CB2018
Encoding of Multiple Reward-Related Computations in Transient and Sustained High-Frequency Activity in Human OFC.
Article in Current biology : CB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis comparing the effectiveness and safety of repetitive transcranial magnetic stimulation versus theta burst stimulation for treatment-resistant depression.Frontiers in psychiatry · 2024Pooled it
- Intracranial recordings in humans reveal differential contributions of medial and lateral orbitofrontal cortex to approach-avoidance decision-making.Nature neuroscience · 2026Article
- Hippocampal-cingulate dynamics in the human brain link reinforcement-learning and memory.bioRxiv : the preprint server for biology · 2026Article
- Electrophysiological dissociation of human posterior cingulate cortex contributions to value- and memory-based decision-making.bioRxiv : the preprint server for biology · 2026Article
- Closed-loop readout of anterior insula high-gamma activity steers value-based decisions.Nature communications · 2026Article
- Reward circuit local field potential modulations precede risk taking.Brain : a journal of neurology · 2025Article
- Orbitofrontal High-Gamma Reflects Spike-Dissociable Value and Decision Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Distributed Intracranial Activity Underlying Human Decision-making Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Intracranial substrates of meditation-induced neuromodulation in the amygdala and hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Simultaneous intracranial recordings of interacting brains reveal neurocognitive dynamics of human cooperation.Nature neuroscience · 2025Article
- Reward recalibrates rule representations in human amygdala and hippocampus intracranial recordings.Nature communications · 2024Article
- Multiattribute Decision-making in Macaques Relies on Direct Attribute Comparisons.Journal of cognitive neuroscience · 2024Article
- Beta and theta oscillations track effort and previous reward in the human basal ganglia and prefrontal cortex during decision making.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Neural interactions in the human frontal cortex dissociate reward and punishment learning.eLife · 2024Article
- Encoding of Predictive Associations in Human Prefrontal and Medial Temporal Neurons During Pavlovian Appetitive Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Temporally organized representations of reward and risk in the human brain.Nature communications · 2024Article
- Elevated phase amplitude coupling as a depression biomarker in epilepsy.Epilepsy & behavior : E&B · 2024Article
- Ramping dynamics and theta oscillations reflect dissociable signatures during rule-guided human behavior.Nature communications · 2024Article
- Beta and theta oscillations track effort and previous reward in human basal ganglia and prefrontal cortex during decision making.bioRxiv : the preprint server for biology · 2023Article
- Electrophysiological population dynamics reveal context dependencies during decision making in human frontal cortex.Nature communications · 2023Article
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Abstract
Human orbitofrontal cortex (OFC) has long been implicated in value-based decision making. In recent years, convergent evidence from human and model organisms has further elucidated its role in representing reward-related computations underlying decision making. However, a detailed description of these processes remains elusive due in part to (1) limitations in our ability to observe human OFC neural dynamics at the timescale of decision processes and (2) methodological and interspecies differences that make it challenging to connect human and animal findings or to resolve discrepancies when they arise. Here, we sought to address these challenges by conducting multi-electrode electrocorticography (ECoG) recordings in neurosurgical patients during economic decision making to elucidate the electrophysiological signature, sub-second temporal profile, and anatomical distribution of reward-related computations within human OFC. We found that high-frequency activity (HFA) (70-200 Hz) reflected multiple valuation components grouped in two classes of valuation signals that were dissociable in temporal profile and information content: (1) fast, transient responses reflecting signals associated with choice and outcome processing, including anticipated risk and outcome regret, and (2) sustained responses explicitly encoding what happened in the immediately preceding trial. Anatomically, these responses were widely distributed in partially overlapping networks, including regions in the central OFC (Brodmann areas 11 and 13), which have been consistently implicated in reward processing in animal single-unit studies. Together, these results integrate insights drawn from human and animal studies and provide evidence for a role of human OFC in representing multiple reward computations.
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