Evidence map›Paper›PMID 30220458›Full record

ArticleCell2018

An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis.

Ben Roediger, Quintin Lee, Shweta Tikoo, Joanna C A Cobbin, James M Henderson, Mika Jormakka, Matthew B O'Rourke, Matthew P Padula, Natalia Pinello, Marisa Henry and 20 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 131 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Guidance on Establishing Health Monitoring Panels for Laboratory Mice to Reflect Contemporary Pathogen Prevalence.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Review
  6. Article
  7. European Hedgehogs as Hosts of Chaphamaparvovirus, Italy.Animals : an open access journal from MDPI · 2024
    Article
  8. Article
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  10. Review
  11. Article
  12. Article
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  18. Article
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  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors at 10 institutions in 4 countries.

Ben RoedigerCentenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia. Electronic address: b.roediger@centenary.org.au.
Quintin LeeCentenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
Shweta TikooCentenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
Joanna C A CobbinMarie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
James M HendersonCentenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
Mika JormakkaCentenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
Matthew B O'RourkeMass Spectrometry Core Facility, University of Sydney, Sydney, NSW 2006, Australia; Proteomics Core Facility, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Matthew P PadulaProteomics Core Facility, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Natalia PinelloCentenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
Marisa HenryCentenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia; Laboratory Animal Services, University of Sydney, Sydney, NSW 2006, Australia.
Maria WynneCentenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia; Laboratory Animal Services, University of Sydney, Sydney, NSW 2006, Australia.
Sara F SantagostinoLaboratory of Comparative Pathology, Center of Comparative Medicine and Pathology, Memorial Sloan Kettering Cancer Center, The Rockefeller University, Weill Cornell Medicine, New York, NY 10065, USA.
Cory F BraytonDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Lorna RasmussenCerberus Sciences, Thebarton, SA 5031, Australia.
Leszek LisowskiChildren's Medical Research Institute, University of Sydney, Sydney, NSW 2006, Australia; Military Institute of Hygiene and Epidemiology, Biological Threats Identification and Countermeasure Centre, Puławy 24-100, Poland.
Szun S TayCentenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
David C HarrisCentre for Transplantation and Renal Research, Westmead Institute for Medical Research, University of Sydney, NSW 2006, Australia.
John F BertramMonash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, VIC 3800, Australia.
John P DowlingDepartment of Anatomical Pathology, Monash Medical Centre, Clayton, VIC 3168, Australia.
Patrick BertolinoCentenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
Jack H LaiSackler School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.
Wengen WuSackler School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.
William W BachovchinSackler School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.
Justin J-L WongCentenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
Mark D GorrellCentenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
Babak ShabanAustralian Genomics Research Facility, Parkville, VIC 3000, Australia; Melbourne Integrative Genomics, University of Melbourne, Parkville, VIC 3010, Australia.
Edward C HolmesMarie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
Christopher J JollyCentenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
Sébastien MonetteLaboratory of Comparative Pathology, Center of Comparative Medicine and Pathology, Memorial Sloan Kettering Cancer Center, The Rockefeller University, Weill Cornell Medicine, New York, NY 10065, USA.
Wolfgang WeningerCentenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia; Discipline of Dermatology, Faculty of Medicine and Health, University of Sydney, NSW 2006, Australia; Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia; Department of Dermatology, Medical University of Vienna, Vienna 1090, Austria. Electronic address: w.weninger@centenary.org.au.
Centenary Institute · AUUniversity of Sydney · AUTufts University · USMemorial Sloan Kettering Cancer Center · USAustralian Genome Research Facility · AUChildren's Medical Research Institute · AUJohns Hopkins University · USMonash Medical Centre · AUMonash University · AUUniversity of Technology Sydney · AU

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Ferroportin Structure and functionR01DK107309 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JORMAKKA, MIKA, MACKENZIE, BRYAN · 2015 to 2019
$3.0M
NCI NIH HHS P30 CA008748NIDDK NIH HHS R01 DK107309
6 · The paper itself

Abstract

The occurrence of a spontaneous nephropathy with intranuclear inclusions in laboratory mice has puzzled pathologists for over 4 decades, because its etiology remains elusive. The condition is more severe in immunodeficient animals, suggesting an infectious cause. Using metagenomics, we identify the causative agent as an atypical virus, termed "mouse kidney parvovirus" (MKPV), belonging to a divergent genus of Parvoviridae. MKPV was identified in animal facilities in Australia and North America, is transmitted via a fecal-oral or urinary-oral route, and is controlled by the adaptive immune system. Detailed analysis of the clinical course and histopathological features demonstrated a stepwise progression of pathology ranging from sporadic tubular inclusions to tubular degeneration and interstitial fibrosis and culminating in renal failure. In summary, we identify a widely distributed pathogen in laboratory mice and establish MKPV-induced nephropathy as a new tool for elucidating mechanisms of tubulointerstitial fibrosis that shares molecular features with chronic kidney disease in humans.

Indexed as

AnimalsAustraliaDisease ProgressionFemaleFibrosisHumansKidneyMaleMiceMice, Inbred C57BLNephritis, InterstitialNorth AmericaParvoviridae InfectionsParvoviruschronic kidney diseasefibrosisinclusion body nephropathyParvoviridaeparvovirustubulointerstitial fibrosisviral metagenomics

Identifiers

PMID30220458
PMCPMC6800251
OpenAlexW2889715034

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.