ArticleBreast cancer research and treatment2018
CCN6 regulates IGF2BP2 and HMGA2 signaling in metaplastic carcinomas of the breast.
Article in Breast cancer research and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Integrative analysis of the roles and prognostic value of RNA-binding proteins in papillary renal cell carcinoma.Discover oncology · 2026Article
- Pattern of SOX9 expression in pleomorphic adenoma, carcinoma ex pleomorphic adenoma, and matrix-producing metaplastic carcinoma of the breast lends support to common biology.Virchows Archiv : an international journal of pathology · 2025Article
- IMPlications of IMP2 in RNA Biology and Disease.International journal of molecular sciences · 2025Review
- Lycorine affects tamoxifen resistance of breast cancer via mTranslational cancer research · 2024Article
- CCN6 Suppresses Metaplastic Breast Carcinoma by Antagonizing Wnt/β-Catenin Signaling to Inhibit EZH2-Driven EMT.Cancer research · 2024Article
- The emerging role and mechanism of HMGA2 in breast cancer.Journal of cancer research and clinical oncology · 2024Review
- A Comprehensive Landscape of Imaging Feature-Associated RNA Expression Profiles in Human Breast Tissue.Sensors (Basel, Switzerland) · 2023Article
- The matricellular protein CCN6 differentially regulates mitochondrial metabolism in normal epithelium and in metaplastic breast carcinomas.Journal of cell communication and signaling · 2022Article
- Research progress on RNA-binding proteins in breast cancer.Oncology letters · 2022Review
- Expression profile, clinical significance and biological functions of IGF2BP2 in esophageal squamous cell carcinoma.Experimental and therapeutic medicine · 2022Article
- The Involvement of Insulin-Like Growth Factor 2 Messenger Ribonucleic Acid-Binding Protein 2 in the Regulation of the Expression of Breast Cancer-Related Genes.Breast cancer (Dove Medical Press) · 2022Article
- Article
- Identification of the function and mechanism of m6A reader IGF2BP2 in Alzheimer's disease.Aging · 2021Article
- IGF2BP2 knockdown inhibits LPS-induced pyroptosis in BEAS-2B cells by targeting caspase 4, a crucial molecule of the non-canonical pyroptosis pathway.Experimental and therapeutic medicine · 2021Article
- The emerging role of RNA N6-methyladenosine methylation in breast cancer.Biomarker research · 2021Review
- Expression and clinical prognostic value of m6A RNA methylation modification in breast cancer.Biomarker research · 2021Article
- The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers.Cancer cell international · 2021Review
- Molecular Characteristics, Prognostic Value, and Immune Characteristics of mFrontiers in oncology · 2021Article
- Quantitative proteomic landscape of metaplastic breast carcinoma pathological subtypes and their relationship to triple-negative tumors.Nature communications · 2020Article
- Clinical Significance of an m6A Reader Gene,Frontiers in molecular biosciences · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
purposeMetaplastic breast carcinomas are an aggressive subtype of triple-negative breast cancer (TNBC) in which part or all of the adenocarcinoma transforms into a non-glandular component (e.g., spindled, squamous, or heterologous). We discovered that mammary-specific Ccn6/Wisp3 knockout mice develop mammary carcinomas with spindle and squamous differentiation that share upregulation of the oncofetal proteins IGF2BP2 (IMP2) and HMGA2 with human metaplastic carcinomas. Here, we investigated the functional relationship between CCN6, IGF2BP2, and HMGA2 proteins in vitro and in vivo, and their expression in human tissue samples.
methodsMMTV-cre;Ccn6
resultsCCN6 regulates IGF2BP2 and HMGA2 protein expression in MMTV-cre;Ccn6
conclusionsThese data shed light into the pathogenesis of metaplastic carcinoma and demonstrate a novel CCN6/IGF2BP2/HMGA2 oncogenic pathway with biomarker and therapeutic implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.