ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2019
Prognostic value of paravertebral muscle density in patients with spinal metastases from gastrointestinal cancer.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Sarcopenia in Patients With Spinal Metastasis: A Systematic Review and Meta-Analysis of Retrospective Cohort Studies.Frontiers in oncology · 2022Pooled it
- Sarcopenia and the management of spinal disease in the elderly.GeroScience · 2025Review
- The utilization of hypoalbuminemia as a prognostic metric in patients with spinal metastases: A scoping review.Brain & spine · 2025Review
- Malnutrition in Spine Oncology: Where Are We and What Are We Measuring?Global spine journal · 2025Article
- Use of 3D-CT-derived psoas major muscle volume in defining sarcopenia in colorectal cancer.BMC cancer · 2024Article
- Lumbar muscle involvement in the occurrence of osteoporotic vertebral fracture.Research in diagnostic and interventional imaging · 2024Article
- CT evaluation for sarcopenia involving the psoas and paravertebral muscles in patients with total hip arthroplasty.Skeletal radiology · 2022Article
- Article
- Muscle-Related Parameters as Determinants of Survival in Patients with Stage I-III Gastric Cancer Undergoing Gastrectomy.Journal of Cancer · 2021Article
- Association Between the Normal-Density Psoas Muscle Index and Handgrip Strength or Gait Speed in Maintenance Hemodialysis Patients.Frontiers in medicine · 2021Article
- Computed tomography-based psoas skeletal muscle area and radiodensity are poor sentinels for whole L3 skeletal muscle values.Clinical nutrition (Edinburgh, Scotland) · 2020Article
- Clinical Significance of Paraspinal Muscle Parameters as a prognostic factor for survival in Gastric Cancer Patients who underwent Curative Surgical Resection.Journal of Cancer · 2020Article
- Evaluation of muscle mass and intramuscular fatty infiltration in dogs with hypercortisolism and their association with prognosis.Journal of veterinary internal medicineArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMorphometric analyses have shown that trunk muscle mass and density are associated with mortality in cancer patients. Because of the low incidence of spinal metastasis from gastrointestinal cancer and the limited life expectancy of these patients, few studies have been reported in this population. We evaluated the prognostic value of trunk muscle area and density in predicting overall survival.
methodsThe data from 78 patients with spinal metastases from gastrointestinal cancer, collected from February 2009 to July 2016, were evaluated. Psoas muscle and paravertebral muscle area and density were measured at the L3 level on CT scans taken at the time nearest to the diagnosis of spinal metastasis. Cox proportional hazards analysis was performed to evaluate the factors independently associated with overall survival.
resultsThe mean patient age was 68.3 years (range, 42-88 years). The overall median survival time was 4.8 months: 2.2 months in the extremely rapid growth group (stomach, biliary tract, and pancreas) and 7.6 months in the rapid growth group (esophagus, liver, and colorectum). Multivariate analyses showed that lower paravertebral muscle density (HR 2.23 [95% CI 1.24-3.99], p = 0.007), extremely rapid growth group, presence of abnormal laboratory data, poor performance status, and chemotherapy after spinal metastasis were independent prognostic factors.
conclusionsMedian overall survival was poor among patients with spinal metastases from gastrointestinal carcinoma, especially among those with gastric, biliary tract, or pancreatic cancer. Lower paravertebral muscle density was an independent poor prognostic factor in patients with spinal metastases from gastrointestinal cancer.
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