ArticlePsychopharmacology2018
The SSRI citalopram increases the sensitivity of the human circadian system to light in an acute dose.
Article in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 59 citations in OpenAlex.
- Trial
- Trial
- Considerations and guidelines for photic measurement in field studies of the physiological effects of light.Npj biological timing and sleep · 2026Review
- Who Needs Bright Light and When? Mapping the Interactions of Lighting Environments and Individual Differences in Circadian Light Sensitivity.Journal of biological rhythms · 2026Article
- Naturalistic light exposure patterns in relation to medication status, mood symptoms, and chronotype.Npj biological timing and sleep · 2026Article
- Production, Mechanisms, and Therapeutic Strategies of Tryptophan Metabolites in CNS Diseases.Molecular neurobiology · 2025Review
- Role of chronotype in depression.World journal of psychiatry · 2025Review
- Mental health and sleep correlates of self-reported outdoor daylight exposure in over 13,000 adults with depression.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Circadian and sleep-wake rhythm alterations in isolated REM sleep behavior disorder: biomarkers of prodromal α-synucleinopathy.Frontiers in neuroscience · 2025Review
- Article
- The sleep-circadian interface: A window into mental disorders.Proceedings of the National Academy of Sciences of the United States of America · 2024Review
- Sleep and circadian rhythm disturbances: plausible pathways to major mental disorders?World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Article
- Seasonality of brain function: role in psychiatric disorders.Translational psychiatry · 2023Review
- Time spent in outdoor light is associated with mood, sleep, and circadian rhythm-related outcomes: A cross-sectional and longitudinal study in over 400,000 UK Biobank participants.Journal of affective disorders · 2021Article
- Antidepressants and Circadian Rhythm: Exploring Their Bidirectional Interaction for the Treatment of Depression.Pharmaceutics · 2021Review
- Circadian disruption and human health.The Journal of clinical investigation · 2021Review
- Review
- Melanopsin-driven pupil response in summer and winter in unipolar seasonal affective disorder.Journal of affective disorders · 2021Article
- Melanopsin-mediated pupillary responses in bipolar disorder-a cross-sectional pupillometric investigation.International journal of bipolar disorders · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleDisturbances of the circadian system are common in depression. Though they typically subside when depression is treated with antidepressants, the mechanism by which this occurs is unknown. Despite being the most commonly prescribed class of antidepressants, the effect of selective serotonin reuptake inhibitors (SSRIs) on the human circadian clock is not well understood.
objectiveTo examine the effect of the SSRI citalopram (30 mg) on the sensitivity of the human circadian system to light.
methodsThis study used a double-blind, placebo-controlled, within-subjects, crossover design. Participants completed two melatonin suppression assessments in room level light (~ 100 lx), taking either a single dose of citalopram 30 mg or a placebo at the beginning of each light exposure. Melatonin suppression was calculated by comparing placebo and citalopram light exposure conditions to a dim light baseline.
resultsA 47% increase in melatonin suppression was observed after administration of an acute dose of citalopram, with all participants showing more suppression after citalopram administration (large effect, d = 1.54). Further, melatonin onset occurred later under normal room light with citalopram compared to placebo.
conclusionsIncreased sensitivity of the circadian system to light could assist in explaining some of the inter-individual variability in antidepressant treatment responses, as it is likely to assist in recovery in some patients, while causing further disruption for others.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.