ReviewReviews in endocrine & metabolic disorders2018
Fertility preservation options in transgender people: A review.
Review in Reviews in endocrine & metabolic disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Fertility preservation for transgender children and young people in paediatric healthcare: a systematic review of ethical considerations.Journal of medical ethics · 2022Pooled it
- Oocyte cryopreservation for fertility preservation in transgender and gender diverse individuals: a SWOT analysis.Journal of assisted reproduction and genetics · 2025Review
- Article
- Extended sperm search and microfreeze for fertility preservation after long-term hormone therapy in transgender women: a report of three cases.AME case reports · 2025Article
- Artificial Gametes and Human Reproduction in the 21st Century: An Ethical Analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- Endometriosis in Transgender Men: Bridging Gaps in Research and Care-A Narrative Review.Biomedicines · 2024Review
- Decision regret, and other mental health outcomes, following fertility preservation in the transgender individual compared to the cisgender woman.Journal of assisted reproduction and genetics · 2024Article
- A Gender-Affirming Approach to Fertility Care for Transgender and Gender-Diverse Patients.O&G open · 2024Article
- Family Building in Transgender Patients: Modern Strategies with Assisted Reproductive Technology Treatment.Transgender health · 2024Article
- The ovaries of transgender men indicate effects of high dose testosterone on the primordial and early growing follicle pool.Reproduction & fertility · 2023Article
- Summary of the ISFP congress, Brussels, 10-12 November, 2022.Journal of assisted reproduction and genetics · 2023Review
- Fertility preservation in pediatric healthcare: a review.Frontiers in endocrinology · 2023Review
- Sperm Cryopreservation Outcomes in Transgender Adolescents Compared with Adolescents Receiving Gonadotoxic Therapy.Transgender health · 2022Article
- Fertility Preservation and Reproductive Potential in Transgender and Gender Fluid Population.Biomedicines · 2022Review
- LGBTQ+ individuals and pregnancy outcomes: A commentary.BJOG : an international journal of obstetrics and gynaecology · 2022Article
- Gender Affirmative Care Clinic: An Overview.Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India · 2022Review
- Comparison between slow freezing and vitrification of ovarian tissue cryopreservation in assigned female at birth transgender people receiving testosterone therapy: data on histological and viability parameters.Journal of assisted reproduction and genetics · 2022Article
- ESSM Position Statement "Sexual Wellbeing After Gender Affirming Surgery".Sexual medicine · 2022Review
- Article
- Standards of Care for the Health of Transgender and Gender Diverse People, Version 8.International journal of transgender health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Gender affirming procedures adversely affect the reproductive potential of transgender people. Thus, fertility preservation options should be discussed with all transpeople before medical and surgical transition. In transwomen, semen cryopreservation is typically straightforward and widely available at fertility centers. The optimal number of vials frozen depends on their reproductive goals and treatment options, therefore a consultation with a fertility specialist is optimal. Experimental techniques including spermatogonium stem cells (SSC) and testicular tissue preservation are technologies currently under development in prepubertal individuals but are not yet clinically available. In transmen, embryo and/or oocyte cryopreservation is currently the best option for fertility preservation. Embryo cryopreservation requires fertilization of the transman's oocytes with a donor or partner's sperm prior to cryopreservation, but this limits his future options for fertilizing the eggs with another partner or donor. Oocyte cryopreservation offers transmen the opportunity to preserve their fertility without committing to a male partner or sperm donor at the time of cryopreservation. Both techniques however require at least a two-week treatment course, egg retrieval under sedation and considerable cost. Ovarian tissue cryopreservation is a promising experimental method that may be performed at the same time as gender affirming surgery but is offered in only a limited amount of centers worldwide. In select places, this method may be considered for prepubertal children, adolescents, and adults when ovarian stimulation is not possible. Novel methods such as in-vitro activation of primordial follicles, in vitro maturation of immature oocytes and artificial gametes are under development and may hold promise for the future.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.