Evidence map›Paper›PMID 30219982›Full record

ArticleJournal of clinical immunology2018

Gastric Cancer Screening in Common Variable Immunodeficiency.

David K van der Poorten, Duncan McLeod, Golo Ahlenstiel, Scott Read, Avelyn Kwok, Cositha Santhakumar, Milan Bassan, Suzanne Culican, David Campbell, Sue W J Wong and 16 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of clinical immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Monitoring patients with uncomplicated common variable immunodeficiency: a systematic review.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022
    Article
  10. Article
  11. Epidemiology ofPeerJ · 2022
    Article
  12. State-of-the-art diagnostic evaluation of common variable immunodeficiency.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2021
    Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 7 institutions in 1 country.

David K van der PoortenDepartment of Gastroenterology and Hepatology, Westmead Hospital, Sydney, NSW, Australia.
Duncan McLeodDepartment of Anatomical Pathology, Westmead Hospital, Sydney, NSW, Australia.
Golo AhlenstielFaculty of Medicine, The University of Sydney, Sydney, NSW, Australia.
Scott ReadStorr Liver Centre, Westmead Institute of Medical Research, Westmead, NSW, Australia.
Avelyn KwokDepartment of Gastroenterology and Hepatology, Concord Repatriation General Hospital, Sydney, NSW, Australia.
Cositha SanthakumarDepartment of Gastroenterology and Hepatology, Concord Repatriation General Hospital, Sydney, NSW, Australia.
Milan BassanDepartment of Gastroenterology and Hepatology, Liverpool hospital, Sydney, NSW, Australia.
Suzanne CulicanNSW Health Pathology, Sydney, NSW, Australia.
David CampbellNSW Health Pathology, Sydney, NSW, Australia.
Sue W J WongNSW Health Pathology, Sydney, NSW, Australia.
Louise EvansFaculty of Medicine, The University of New South Wales, Sydney, NSW, Australia.
Bilel JidehDepartment of Gastroenterology and Hepatology, Westmead Hospital, Sydney, NSW, Australia.
Alisa KaneDepartment of Immunology, Liverpool Hospital, Sydney, NSW, Australia.
Constance H KatelarisDepartment of Immunology, Campbelltown Hospital, Campbelltown, NSW, Australia.
Karuna KeatDepartment of Immunology, Campbelltown Hospital, Campbelltown, NSW, Australia.
Yanna KoDepartment of Immunology, Concord Repatriation General Hospital, Sydney, NSW, Australia.
Jessie A LeeDepartment of Immunology, Liverpool Hospital, Sydney, NSW, Australia.
Sandhya LimayeFaculty of Medicine, The University of Sydney, Sydney, NSW, Australia.
Ming Wei LinFaculty of Medicine, The University of Sydney, Sydney, NSW, Australia.
Ari MuradDepartment of Immunology, Liverpool Hospital, Sydney, NSW, Australia.
Martina RaffertyDepartment of Immunology, Concord Repatriation General Hospital, Sydney, NSW, Australia.
Dan SuanFaculty of Medicine, The University of Sydney, Sydney, NSW, Australia.
Sanjay SwaminathanFaculty of Medicine, The University of Sydney, Sydney, NSW, Australia.
Sean D RimintonFaculty of Medicine, The University of Sydney, Sydney, NSW, Australia.
Catherine ToongNSW Health Pathology, Sydney, NSW, Australia.
Lucinda J BerglundFaculty of Medicine, The University of Sydney, Sydney, NSW, Australia. Lucinda.Berglund@health.nsw.gov.au.ORCID 0000-0002-6595-9947
The University of Sydney · AULiverpool Hospital · AUNew South Wales Department of Health · AUConcord Repatriation General Hospital · AUCamden and Campbelltown Hospitals · AUWestmead Hospital · AUWestmead Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Individuals with common variable immunodeficiency (CVID) have an increased risk of gastric cancer, and gastrointestinal lymphoma, yet screening for premalignant gastric lesions is rarely offered routinely to these patients. Proposed screening protocols are not widely accepted and are based on gastric cancer risk factors that are not applicable to all CVID patients. Fifty-two CVID patients were recruited for screening gastroscopy irrespective of symptoms or blood results and were compared to 40 controls presenting for gastroscopy for other clinical indications. Overall, 34% of CVID patients had intestinal metaplasia (IM), atrophic gastritis or moderate to severe non-atrophic gastritis, which can increase the risk of gastric cancer, compared to 7.5% of controls (p < 0.01). Focal nodular lymphoid hyperplasia, a precursor lesion for gastrointestinal lymphoma, was seen in eight CVID patients (16%), one of whom was diagnosed with gastrointestinal lymphoma on the same endoscopy. High-risk gastric pathology was associated with increased time since diagnosis of CVID, smoking, Helicobacter pylori, a low-serum pepsinogen I concentration, and diarrhea, but not pepsinogen I/II ratio, iron studies, vitamin B12 levels or upper gastrointestinal symptoms. There was a lower rate of detection of IM when fewer biopsies were taken, and IM and gastric atrophy were rarely predicted by the endoscopist macroscopically, highlighting the need for standardized biopsy protocols. The prevalence of premalignant gastric lesions in patients with CVID highlights the need for routine gastric screening. We propose a novel gastric screening protocol to detect early premalignant lesions and reduce the risk of gastric cancer and gastric lymphoma in these patients.

Indexed as

AdolescentAdultAgedAged, 80 and overBiomarkersBiopsyCommon Variable ImmunodeficiencyEarly Detection of CancerFemaleGastritis, AtrophicGastroscopyHelicobacter InfectionsHumansMaleMass ScreeningMetaplasiaBiomarkersCommon variable immunodeficiencyCVIDgastric cancergastroscopyintestinal metaplasia

Identifiers

PMID30219982
OpenAlexW2891732767

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.