Evidence map›Paper›PMID 30219789›Full record

ArticleThe Journal of biological chemistry2018

Inhibitory effects of cannabidiol on voltage-dependent sodium currents.

Mohammad-Reza Ghovanloo, Noah Gregory Shuart, Janette Mezeyova, Richard A Dean, Peter C Ruben, Samuel J Goodchild

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 3 pooled it
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 3 syntheses or guidelines pooled it, 201 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. (+)-Trans-Cannabidiol Is an Agonist at Human CBPharmacology research & perspectives · 2026
    Article
  8. The psychoactive cannabinoid THC inhibits peripheral nociceptors by targeting NaNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  9. Review
  10. Article
  11. Overlapping pathways of migraine and the endocannabinoid system: Potential therapeutic targets.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
  12. Article
  13. Review
  14. The Pharmacological Profile of Plant-Derived Cannabinoids In Vitro.Current topics in behavioral neurosciences · 2026
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mohammad-Reza GhovanlooFrom the Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada and.ORCID 0000-0002-2171-0744
Noah Gregory Shuartthe Department of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, British Columbia V5G 4W8, Canada.
Janette Mezeyovathe Department of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, British Columbia V5G 4W8, Canada.
Richard A Deanthe Department of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, British Columbia V5G 4W8, Canada.
Peter C RubenFrom the Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada and.
Samuel J Goodchildthe Department of Cellular and Molecular Biology, Xenon Pharmaceuticals, Burnaby, British Columbia V5G 4W8, Canada sgoodchild@xenon-pharma.com.
Xenon Pharmaceuticals (Canada) · CASimon Fraser University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CannabidiolGene Expression RegulationHEK293 CellsHumansNAV1.1 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelNeuronsSodiumVoltage-Gated Sodium Channel beta-1 SubunitCannabidiolNAV1.1 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelSCN1A protein, humanSCN1B protein, humanSCN8A protein, humanSodiumVoltage-Gated Sodium Channel beta-1 Subunitcannabidiolcannabinoidcentral nervous system (CNS)electrophysiologyepilepsyKv2.1neuronphytocannabinoidsodium channelvoltage-gated sodium channel

Identifiers

PMID30219789
PMCPMC6204917
OpenAlexW2891640176

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.