Evidence map›Paper›PMID 30219486›Full record

ArticleNeuroscience letters2018

Proteasome limits plasticity-related signaling to the nucleus in the hippocampus.

Anirudh Vashisht, Svitlana V Bach, Dustin Fetterhoff, James W Morgan, Maria McGee, Ashok N Hegde

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anirudh VashishtDepartment of Neurobiology and Anatomy & Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC, 27157, USA; Department of Biological and Environmental Sciences, Georgia College and State University, Milledgeville, GA, 31061, USA.
Svitlana V BachDepartment of Neurobiology and Anatomy & Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Dustin FetterhoffDepartment of Neurobiology and Anatomy & Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
James W MorganDepartment of Neurobiology and Anatomy & Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Maria McGeePlastic and Reconstructive Surgery Research, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Ashok N HegdeDepartment of Neurobiology and Anatomy & Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC, 27157, USA; Department of Biological and Environmental Sciences, Georgia College and State University, Milledgeville, GA, 31061, USA. Electronic address: ashok.hegde@gcsu.edu.

Funding

Local Mechanisms Underlying Synaptic PlasticityR01NS066583 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HEGDE, ASHOK N · 2009 to 2012
$1.3M
Nuclear Role of the Proteasome in Synaptic PlasticityR15NS098405 · NINDS · GEORGIA COLLEGE AND STATE UNIVERSITY · PI HEGDE, ASHOK N · 2016 to 2016
$381k
NINDS NIH HHS R01 NS066583NINDS NIH HHS R15 NS098405
6 · The paper itself

Abstract

Proteolysis by the ubiquitin-proteasome pathway has pleiotropic effects on both induction and maintenance of long-term synaptic plasticity. In this study, we examined the effect of proteasome inhibition on signaling to the nucleus during late-phase long-term potentiation. When a subthreshold L-LTP induction protocol was used, proteasome inhibition led to a significant increase in phosphorylated CREB (pCREB) in the nucleus. Inhibitors of cAMP-dependent protein kinase/protein kinase A, extracellular signal-regulated kinase and cGMP-dependent protein kinase/protein kinase G all blocked the proteasome-inhibition-mediated increase in nuclear pCREB after subthreshold stimulation. These results lay the groundwork for understanding a novel role for the proteasome in limiting signaling to the nucleus in the absence of adequate synaptic stimulation.

Indexed as

AnimalsCell NucleusCyclic AMP Response Element-Binding ProteinHippocampusLong-Term PotentiationMaleMiceMice, Inbred C57BLNeuronal PlasticityOrgan Culture TechniquesProteasome Endopeptidase ComplexProteasome InhibitorsSignal TransductionCreb1 protein, mouseCyclic AMP Response Element-Binding ProteinProteasome Endopeptidase ComplexProteasome InhibitorsGene expressionLong-term potentiationProtein degradationProtein kinaseTranscription factor

Identifiers

PMID30219486
PMCPMC6231982

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.