Evidence map›Paper›PMID 30219052›Full record

Trial reportBMC public health2018

Effects of alternate day calorie restriction and exercise on cardio-metabolic risk factors in overweight and obese adults: an exploratory randomized controlled study.

Minsuk Oh, Sue Kim, Ki-Yong An, Jihee Min, Hyuk In Yang, Junga Lee, Mi Kyung Lee, Dong-Il Kim, Hye-Sun Lee, Ji-Won Lee and 1 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03652532 (Effects of Alternate Day Fasting and Exercise on Body Weight, Visceral Fat, and Metabolic Parameters in Overweight or Obese Adults), which is not on this map. Cited by 29 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 14 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03652532 nacompletednot on this map

Effects of Alternate Day Fasting and Exercise on Body Weight, Visceral Fat, and Metabolic Parameters in Overweight or Obese Adults: A Randomized Controlled Trial

TypeinterventionalSponsorGangnam Severance HospitalRan2014 to 2016Enrolled100ConditionsOverweight, Obesity, Diet Modification, ExerciseArmsAlternate Day Fasting, Exercise
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 14 syntheses or guidelines pooled it, 54 citations in OpenAlex.

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  19. A Narrative Review of Intermittent Fasting With Exercise.Journal of the Academy of Nutrition and Dietetics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Minsuk OhDepartment of Health and Human Physiology, University of Iowa, Iowa City, IA, USA.
Sue KimDepartment of Family Medicine, Severance Hospital, Yonsei University, College of Medicine, Seoul, South Korea.
Ki-Yong AnFaculty of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada.
Jihee MinDepartment of Sport and Leisure Studies, Yonsei University, Seoul, South Korea.
Hyuk In YangDepartment of Sport and Leisure Studies, Yonsei University, Seoul, South Korea.
Junga LeeGraduate School of Sport Science, Kyung Hee University, Yongin-Si, South Korea.
Mi Kyung LeeDepartment of Sport and Leisure Studies, Yonsei University, Seoul, South Korea.
Dong-Il KimDepartment of Professional Therapy, Graduate School of Professional Therapy, Gachon University, Geonggi-do, South Korea.
Hye-Sun LeeDepartment of Biostatistics, Yonsei University, College of Medicine, Seoul, South Korea.
Ji-Won LeeDepartment of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. INDI5645@yuhs.ac.
Justin Y JeonDepartment of Sport and Leisure Studies, Yonsei University, Seoul, South Korea. jjeon@yonsei.ac.kr.
Yonsei University · KRKyung Hee University · KRGachon University · KRSeverance Hospital · KRUniversity of Alberta · CAUniversity of Iowa · US

Funding

Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning, Republic of Korea NRF-2013M3A9B6046416the Ministry of Education of the Republic of Korea and the National Research Foundation of Korea NRF-2015S1A5B8036349Yonsei University College of Medicine 6-2013-0021
6 · The paper itself

Abstract

backgroundIt has been recognized that alternate day calorie restriction (ADCR) or exercise has positive effects on cardio-metabolic risk factors. It is unclear whether the combined effect of ADCR and exercise (aerobic + resistance training) influences risk. We investigated effects of an 8-week ADCR and exercise program (aerobic + resistance training) on cardio-metabolic risk factors in overweight and obese adults.

methodsThis study randomized 45 overweight or obese but healthy adults (F = 26, M = 19; aged about 32 to 40 years) into 4 groups: ADCR (n = 13), exercise (n = 10), exercise plus ADCR (n = 12), and control (n = 10) for 8 weeks. Body composition, blood lipids profile, and insulin resistance were measured. The intention to treat (ITT) method was used to analyze all participants that were randomized.

resultsA total of 35 participants completed the trial (78%). Body weight, body mass index, waist circumference, fat mass and percent body fat were reduced in the exercise plus ADCR group (- 3.3 ± 2.4 kg, p < 0.01; - 1.3 ± 1.0 kg/m

conclusionsADCR and exercise both proved to be beneficial, but the combined intervention was most effective at inducing beneficial changes in body weight, body composition, glucose, insulin, insulin resistance and triglyceride in overweight and obese adults.

trial registrationClinicalTrials.gov: NCT03652532 , Registered August 28, 2018, 'retrospectively registered'.

Indexed as

AdultBlood GlucoseBody CompositionBody WeightCaloric RestrictionCardiovascular DiseasesCombined Modality TherapyExercise TherapyFemaleHumansInsulinInsulin ResistanceMaleMetabolic DiseasesObesityOverweightBlood GlucoseInsulinTriglyceridesAlternate day calorie restrictionBody weightExerciseInsulin resistanceObesity

Identifiers

PMID30219052
PMCPMC6139127
OpenAlexW2891836302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.