Evidence map›Paper›PMID 30218980›Full record

ArticleThe Journal of nutritional biochemistry2018

Myeloperoxidase deficiency attenuates systemic and dietary iron-induced adverse effects.

Xia Xiao, Piu Saha, Beng San Yeoh, Jennifer A Hipp, Vishal Singh, Matam Vijay-Kumar

Abstract read
In one paragraph

Article in The Journal of nutritional biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. The Azalea Hypothesis of Alzheimer Disease: A Functional Iron Deficiency Promotes Neurodegeneration.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024
    Review
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xia XiaoDepartment of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Piu SahaDepartment of Physiology & Pharmacology, University of Toledo, OH 43614, USA.
Beng San YeohGraduate Program in Immunology & Infectious Diseases, The Pennsylvania State University, University Park, PA 16802, USA.
Jennifer A HippDepartment of Pathology, University of Toledo, OH 43614, USA.
Vishal SinghDepartment of Physiology & Pharmacology, University of Toledo, OH 43614, USA.
Matam Vijay-KumarDepartment of Physiology & Pharmacology, University of Toledo, OH 43614, USA; Department of Medical Microbiology & Immunology, University of Toledo, OH 43614, USA. Electronic address: MatamVijay.Kumar@utoledo.edu.
University of Toledo · USPennsylvania State University · US

Funding

Role of Lipocalin 2 Inflammatory Bowel DiseaseR01DK097865 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI VIJAY-KUMAR, MATAM · 2013 to 2015
$897k
NIDDK NIH HHS R01 DK097865
6 · The paper itself

Abstract

Iron deficiency is routinely treated with oral or systemic iron supplements, which are highly reactive and could induce oxidative stress via augmenting the activity of proinflammatory enzyme myeloperoxidase (MPO). To investigate the extent to which MPO is involved in iron-induced toxicity, acute (24 h) iron toxicity was induced by intraperitoneal administration of FeSO

Indexed as

Aniline CompoundsAnimalsIron, DietaryIron OverloadMaleMetabolism, Inborn ErrorsMice, Inbred C57BLMice, KnockoutNeutrophilsPeroxidaseReactive Oxygen SpeciesToxicity Tests, Acute4-aminobenzhydrazideAniline CompoundsIron, DietaryPeroxidaseReactive Oxygen SpeciesAcute phase proteinsIron overloadMPONeutrophilsProinflammatory cytokinesReactive oxygen species

Identifiers

PMID30218980
PMCPMC6263781
OpenAlexW2888449936

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.