Evidence map›Paper›PMID 30218742›Full record

ArticleDiabetes research and clinical practice2018

Epidemiology of childhood-onset type 1 diabetes in Azerbaijan: Incidence, clinical features, biochemistry, and HLA-DRB1 status.

Gunduz Ahmad Ahmadov, Denira Govender, Mark Alvin Atkinson, Rumiyya Anvar Sultanova, Amalia Abdulla Eubova, Clive Henry Wasserfall, Steven John Mack, Julie Ann Lane, Janelle Annette Noble, Graham David Ogle

Open access · greenAbstract read
In one paragraph

Article in Diabetes research and clinical practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Diabetes Study of Children of Diverse Ethnicity and Race: Study design.Diabetes/metabolism research and reviews · 2024
    Observational
  4. Article
  5. Review
  6. Article
  7. The relationship between GAD65 autoantibody and the risk of T1DM onset.Journal of diabetes and metabolic disorders · 2022
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Gunduz Ahmad AhmadovEndocrine Centre, Binagadi, Baku City, Azerbaijan; 6th Children's Hospital, Baku City, Azerbaijan; Azerbaijan Medical University, Baku City, Azerbaijan.
Denira GovenderInternational Diabetes Federation Life for a Child Program, Glebe, NSW 2037, Australia; Sydney Medical School, University of Sydney, Sydney 2006, Australia.
Mark Alvin AtkinsonDepartment of Pathology, Immunology and Laboratory Medicine, College of Medicine, Diabetes Institute, University of Florida, Gainesville, FL 32610, USA; Department of Pediatrics, College of Medicine, Diabetes Institute, University of Florida, Gainesville, FL 32610, USA.
Rumiyya Anvar Sultanova6th Children's Hospital, Baku City, Azerbaijan.
Amalia Abdulla EubovaAzerbaijan Medical University, Baku City, Azerbaijan.
Clive Henry WasserfallDepartment of Pathology, Immunology and Laboratory Medicine, College of Medicine, Diabetes Institute, University of Florida, Gainesville, FL 32610, USA.
Steven John MackChildren's Hospital Oakland Research Institute, Oakland, CA 94609, USA.
Julie Ann LaneChildren's Hospital Oakland Research Institute, Oakland, CA 94609, USA.
Janelle Annette NobleChildren's Hospital Oakland Research Institute, Oakland, CA 94609, USA.
Graham David OgleInternational Diabetes Federation Life for a Child Program, Glebe, NSW 2037, Australia; Diabetes NSW, Glebe 2037, NSW, Australia. Electronic address: grahamo@diabetesnsw.com.au.
Azerbaijan Medical University · AZUniversity of Florida · USDiabetes Australia · AUUniversity of Sydney · AU

Funding

Project 3P01AI042288 · NIAID · UNIVERSITY OF FLORIDA · PI Todd Michael Brusko · 1997 to 2026
$32.9M
Integrated Exchange and Storage of Current- and Future-Generation Immunogenomic DataR01AI128775 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JILL Allison HOLLENBACH, STEVEN JOHN MACK · 2017 to 2026
$4.5M
Integrated Exchange & Storage of Current and Future-Generation Immunogenomic DataR01GM109030 · NIGMS · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI HOLLENBACH, JILL ALLISON, MACK, STEVEN JOHN · 2014 to 2016
$919k
NIAID NIH HHS P01 AI042288NIAID NIH HHS R01 AI128775NIGMS NIH HHS R01 GM109030
6 · The paper itself

Abstract

aimsDetermine the incidence and typology of diabetes in children in Azerbaijan.

methodsClinical features, C-peptide, autoantibodies (glutamic acid decarboxylase 65 (GAD65) and islet antigen 2 (IA-2)), and HLA-DRB1 status were studied in 106 subjects <18 years of age who were recently diagnosed. 104 cases were consecutive. Incidence was determined for Baku and Absheron regions, where ascertainment is estimated to be essentially 100%.

results104 of the 106 (98%) were diagnosed with type 1 diabetes, one with type 2 diabetes and one with atypical diabetes. Type 1 diabetes incidence in Baku City and Absheron was 7.05 per 100,000 population <15 years per year. Peak age of onset was 10 years. There was a slight male preponderance (male:female 1.17:1), and no temporal association with seasons. Almost all type 1 diabetes subjects presented with classic symptoms including a high incidence (58%) of diabetic ketoacidosis. 86% presented with low C-peptide values (<0.13 nmol/L, <0.40 ng/mL) and 74% were positive for at least one type 1 diabetes-related autoantibody.

conclusionsAzerbaijan has a moderate type 1 diabetes incidence and clinical, biochemical and genetic features similar to that in European populations.

Indexed as

AdolescentAutoantibodiesAzerbaijanBiomarkersChildChild, PreschoolC-PeptideDiabetes Mellitus, Type 1FemaleHLA-DRB1 ChainsHumansIncidenceInfantMaleAutoantibodiesBiomarkersC-PeptideHLA-DRB1 ChainsAutoimmunityAzerbaijanChildhood diabetesHLAIncidence

Identifiers

PMID30218742
PMCPMC6384092
OpenAlexW2890785519

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.