Evidence map›Paper›PMID 30218400›Full record

ArticleMolecular neurobiology2019

Molecular Association of Glia Maturation Factor with the Autophagic Machinery in Rat Dopaminergic Neurons: a Role for Endoplasmic Reticulum Stress and MAPK Activation.

Govindhasamy Pushpavathi Selvakumar, Shankar S Iyer, Duraisamy Kempuraj, Mohammad Ejaz Ahmed, Ramasamy Thangavel, Iuliia Dubova, Sudhanshu P Raikwar, Smita Zaheer, Asgar Zaheer

Open access · greenAbstract read
In one paragraph

Article in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  8. Next Generation Precision Medicine: CRISPR-mediated Genome Editing for the Treatment of Neurodegenerative Disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019
    Review
  9. Article
  10. Glia Maturation Factor in the Pathogenesis of Alzheimer's disease.Open access journal of neurology & neurosurgery · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Govindhasamy Pushpavathi SelvakumarHarry S. Truman Memorial Veterans Hospital, Columbia, MO, USA.
Shankar S IyerHarry S. Truman Memorial Veterans Hospital, Columbia, MO, USA.
Duraisamy KempurajHarry S. Truman Memorial Veterans Hospital, Columbia, MO, USA.
Mohammad Ejaz AhmedHarry S. Truman Memorial Veterans Hospital, Columbia, MO, USA.
Ramasamy ThangavelHarry S. Truman Memorial Veterans Hospital, Columbia, MO, USA.
Iuliia DubovaHarry S. Truman Memorial Veterans Hospital, Columbia, MO, USA.
Sudhanshu P RaikwarHarry S. Truman Memorial Veterans Hospital, Columbia, MO, USA.
Smita ZaheerHarry S. Truman Memorial Veterans Hospital, Columbia, MO, USA.
Asgar ZaheerHarry S. Truman Memorial Veterans Hospital, Columbia, MO, USA. zaheera@health.missouri.edu.ORCID http://orcid.org/0000-0003-3344-0371
University of Missouri Hospital · USHarry S. Truman Memorial Veterans' Hospital · US

Funding

GMF-dependent neuroinflammation and neurodegenerationR01NS073670 · NINDS · UNIVERSITY OF MISSOURI-COLUMBIA · PI ZAHEER, ASGAR · 2011 to 2015
$1.6M
Therapeutic potential of GMF suppresssion in inflammation and neurodegenerationR01AG048205 · NIA · UNIVERSITY OF MISSOURI-COLUMBIA · PI ZAHEER, ASGAR · 2015 to 2019
$1.6M
Glia maturation factor dependent mast cell activation in Parkinson's diseaseI01BX002477 · VA · IOWA CITY VA MEDICAL CENTER · PI ZAHEER, ASGAR · 2015 to 2017
–
BLRD VA I01 BX002477National Institutes of Health AG048205NIA NIH HHS R01 AG048205NINDS NIH HHS R01 NS073670Office of Academic Affiliations, Department of Veterans Affairs I01BX002477
6 · The paper itself

Abstract

Parkinson's disease (PD) is one of the several neurodegenerative diseases where accumulation of aggregated proteins like α-synuclein occurs. Dysfunction in autophagy leading to this protein build-up and subsequent dopaminergic neurodegeneration may be one of the causes of PD. The mechanisms that impair autophagy remain poorly understood. 1-Methyl-4-phenylpiridium ion (MPP

Indexed as

AutophagyEndoplasmic Reticulum Stressalpha-SynucleinAnimalsAutophagosomesBeclin-1BiomarkersCell NucleusCells, CulturedDopaminergic NeuronsEnzyme ActivationGlia Maturation FactorLysosomesMiceMitogen-Activated Protein KinasesProtein Aggregatesalpha-SynucleinBeclin-1BiomarkersGlia Maturation FactorMitogen-Activated Protein KinasesProtein AggregatesSequestosome-1 ProteinSqstm1 protein, mouseTOR Serine-Threonine KinasesAutophagy dysfunctionGlia maturation factorParkinson’s diseaseProtein aggregation

Identifiers

PMID30218400
PMCPMC6417980
OpenAlexW2891198256

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.