Evidence map›Paper›PMID 30218369›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2018

X-Chromosome Inactivation and Escape from X Inactivation in Mouse.

Wenxiu Ma, Giancarlo Bonora, Joel B Berletch, Xinxian Deng, William S Noble, Christine M Disteche

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenxiu MaDepartment of Statistics, University of California, Riverside, Riverside, CA, USA.
Giancarlo BonoraDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Joel B BerletchDepartment of Pathology, University of Washington, Seattle, WA, USA.
Xinxian DengDepartment of Pathology, University of Washington, Seattle, WA, USA.
William S NobleDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Christine M DistecheDepartment of Pathology, University of Washington, Seattle, WA, USA. cdistech@u.washington.edu.

Funding

University of Washington Center for Nuclear Organization and FunctionU54DK107979 · NIDDK · UNIVERSITY OF WASHINGTON · PI NOBLE, WILLIAM STAFFORD, SHENDURE, JAY ASHOK · 2015 to 2019
$11.8M
Mouse X InactivationR01GM046883 · NIGMS · UNIVERSITY OF WASHINGTON · PI DISTECHE, CHRISTINE M. · 1992 to 2018
$5.9M
Molecular studies of sex chromosome aneuploidyR01GM113943 · NIGMS · UNIVERSITY OF WASHINGTON · PI DISTECHE, CHRISTINE M. · 2015 to 2018
$1.7M
NIDDK NIH HHS U54 DK107979NIGMS NIH HHS R01 GM046883NIGMS NIH HHS R01 GM113943
6 · The paper itself

Abstract

X chromosome inactivation silences one X chromosome in female mammals. However, this silencing is incomplete, and some genes escape X inactivation. We describe methods to determine the chromosome-wide X inactivation status of genes in tissues or cell lines derived from mice using a combination of skewing of X inactivation and allele-specific analyses of gene expression based on RNA-seq.

Indexed as

AllelesX Chromosome InactivationAnimalsCell LineEmbryo, MammalianEpigenomicsFemaleGene Expression ProfilingGene Expression Regulation, DevelopmentalMiceMice, Inbred C57BLPolymorphism, Single NucleotideSequence Analysis, RNAAllelic gene expressionEscape from X inactivationX inactivation

Identifiers

PMID30218369
PMCPMC6269188

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.