ArticleMarine biotechnology (New York, N.Y.)2019
Incorporation of Collagen from Marine Sponges (Spongin) into Hydroxyapatite Samples: Characterization and In Vitro Biological Evaluation.
Article in Marine biotechnology (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Collagen from Marine Sources and Skin Wound Healing in Animal Experimental Studies: a Systematic Review.Marine biotechnology (New York, N.Y.) · 2021Pooled it
- Unraveling the Potential ofBiomacromolecules · 2026Article
- Bioglass-Reinforced Spongin-Like Collagen Scaffolds for Osteoporotic Bone Tissue Engineering.ACS omega · 2026Article
- Casting Skin Dressing Containing Extractions of the Organic Part of Marine Sponges for Wound Healing.ACS applied bio materials · 2025Article
- Influence of L-arginine on hydroxyapatite-based ovine bone graft - AnDental research journal · 2025Article
- Collagen-Based Medical Devices for Regenerative Medicine and Tissue Engineering.Applied biochemistry and biotechnology · 2024Review
- Marine Antioxidants from Marine Collagen and Collagen Peptides with Nutraceuticals Applications: A Review.Antioxidants (Basel, Switzerland) · 2024Review
- Cutting Edge Aquatic-Based Collagens in Tissue Engineering.Marine drugs · 2023Review
- Review
- Potential Biomedical Applications of Collagen Filaments derived from the Marine DemospongesMarine drugs · 2021Article
- Article
- Comparison of Different Methods for Spongin-like Collagen Extraction from Marine Sponges (Membranes · 2021Article
- Marine-Derived Collagen as Biomaterials for Human Health.Frontiers in nutrition · 2021Review
- Fish Collagen: Extraction, Characterization, and Applications for Biomaterials Engineering.Polymers · 2020Review
- Marine collagen scaffolds and photobiomodulation on bone healing process in a model of calvaria defects.Journal of bone and mineral metabolism · 2020Article
- Evaluation of the In Vivo Biological Effects of Marine Collagen and Hydroxyapatite Composite in a Tibial Bone Defect Model in Rats.Marine biotechnology (New York, N.Y.) · 2020Article
- Marine Collagen from Alternative and Sustainable Sources: Extraction, Processing and Applications.Marine drugs · 2020Review
- Marine Collagen as A Promising Biomaterial for Biomedical Applications.Marine drugs · 2019Review
- Influence of the incorporation of marine spongin into a Biosilicate®: an in vitro study.Journal of materials science. Materials in medicine · 2019Article
- Application of a Promising Bone Graft Substitute in Bone Tissue Regeneration: Characterization, Biocompatibility, andBioMed research international · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomaterial-based bone grafts have an important role in the field of bone tissue engineering. One of the most promising classes of biomaterials is collagen, including the ones from marine biodiversity (in general, called spongin (SPG)). Also, hydroxyapatite (HA) has an important role in stimulating bone metabolism. Therefore, this work investigated the association of HA and SPG composites in order to evaluate their physico-chemical and morphological characteristics and their in vitro biological performance. For this, pre-set composite disks were evaluated by means of mass loss after incubation, pH, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and "in vitro" cell viability. pH measurements showed no statistical difference between groups. Moreover, a higher mass loss was observed for HA/SPG70/30 compared to the other groups for all experimental periods. Moreover, SEM representative micrographs showed the degradation of the samples with and without immersion. FTIR analysis demonstrated the absorption peaks for poly(methyl methacrylate) (PMMA), HA, and SPG. A higher L292 cell viability for control and PMMA was observed compared to HA and HA/SPG 90/10. Also, HA/SPG 70/30 showed higher cell viability compared to HA and HA/SPG 90/10 on days 3 and 7 days of culture. Furthermore, HA showed a significant lower MC3T3 cell viability compared to control and HA/SPG 70/30 on day 3 and no significant difference was observed between the composites in the last experimental period. Based on our investigations, it can be concluded that the mentioned composites were successfully obtained, presenting improved biological properties, especially the one mimicking the composition of bone (with 70% of HA and 30% of SPG). Consequently, these data highlight the potential of the introduction of SPG into HA to improve the performance of the graft for bone regeneration applications. Further long-term studies should be carried out to provide additional information concerning the late stages of material degradation and bone healing in the presence of HA/SPG.
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