Trial reportClinical oral investigations2019
Effects of oral prophylaxis including tongue cleaning on halitosis and gingival inflammation in gingivitis patients-a randomized controlled clinical trial.
Trial report in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Emotional and Social Impact of Halitosis on Adolescents and Young Adults: A Systematic Review.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Interventions for managing halitosis.The Cochrane database of systematic reviews · 2019Pooled it
- The effect of periodontal treatment on tongue covering and olfactory function in patients with periodontitis.Odontology · 2026Article
- Effect of tongue hygiene instruction on periodontal patients: an experimental study.BMC oral health · 2026Article
- Knowledge of tongue brushing among school children and their parents, and its effects on children's optimal sugar and salt preferences, dental caries, periodontal diseases, and body mass index.BMC research notes · 2025Article
- Perspectives on tongue coating: etiology, clinical management, and associated diseases - a narrative review.The Saudi dental journal · 2025Review
- Laser Interventions for Intraoral Halitosis: A Systematic Review of Randomized Controlled Trials.Pharmaceutics · 2025Review
- Impact of non-surgical periodontal therapy on self-perceived halitosis, and the senses of smell and taste: a prospective clinical study.BMC oral health · 2025Observational
- Review
- Role of Hydrogen Sulfide in Oral Disease.Oxidative medicine and cellular longevity · 2022Review
- Characterizing the Content Related to Oral Health Education on TikTok.International journal of environmental research and public health · 2021Article
- Defining Metaniches in the Oral Cavity According to Their Microbial Composition and Cytokine Profile.International journal of molecular sciences · 2020Article
- Tongue coating in relationship to gender, plaque, gingivitis and tongue cleaning behaviour in systemically healthy young adults.International journal of dental hygiene · 2020Observational
- Prevalence of Tongue Cleaning Using a Toothbrush: A Questionnaire Survey in Fukui Prefecture, Japan.BioMed research international · 2019Observational
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe objective of this study was to assess the effect of oral prophylaxis including tongue scraping on level of halitosis, clinical periodontal parameters and local cytokine response in gingivitis patients. MATERIALS AND
methodsIn this randomized controlled clinical trial, 36 gingivitis patients were randomly assigned into two subgroups after scaling and polishing. Group 1 received oral hygiene instructions including the use of tongue scraper; group 2 received oral hygiene instructions alone without tongue cleaning. Levels of volatile sulfur compounds (VSC), organoleptic and tongue coating scores, clinical periodontal parameters and gingival crevicular fluid (GCF) samples were collected at baseline and 7 days after oral prophylaxis. GCF samples were analyzed using multiplexing analysis for the simultaneous measurements of cytokines. The Chi-square, Mann-Whitney U, Wilcoxon, and Student's paired and unpaired t tests were used for statistical analysis.
resultsStatistically significant reductions were found in terms of clinical periodontal parameters in both groups. However, significant improvements in VSC levels, organoleptic and tongue coating scores were observed just in tongue scraping group. Moreover, the GCF levels of IL-1β and IL-8 significantly decreased after the treatment in group 1 according to the baseline values.
conclusionThe present study indicated that oral prophylaxis including tongue scraping was effective in improving intra-oral halitosis and pro-inflammatory cytokine response in GCF in gingivitis patients. CLINICAL RELEVANCE: The results suggest that tongue scraping can be taken into consideration in order to manage gingival inflammation as well as VSC levels in gingivitis patients but further clinical studies are required to judge the clinical relevance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.