Evidence map›Paper›PMID 30218137›Full record

ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2018

Postoperative local fractionated radiotherapy for resected single brain metastases.

Ahmad Walid Ayas, Stefan Grau, Karolina Jablonska, Daniel Ruess, Maximilian Ruge, Simone Marnitz, Roland Goldbrunner, Martin Kocher

Abstract read
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In one paragraph

Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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  7. CyberknifeJournal of cancer research and clinical oncology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ahmad Walid AyasDepartment of Radiation Oncology, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany.
Stefan GrauDepartment of Neurosurgery, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany.
Karolina JablonskaDepartment of Radiation Oncology, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany.
Daniel RuessDepartment of Stereotactic and Functional Neurosurgery, Center for Integrated Oncology, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Maximilian RugeDepartment of Stereotactic and Functional Neurosurgery, Center for Integrated Oncology, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Simone MarnitzDepartment of Radiation Oncology, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany.
Roland GoldbrunnerDepartment of Neurosurgery, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany.
Martin KocherDepartment of Radiation Oncology, Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany. martin.kocher@uk-koeln.de.ORCID 0000-0002-5674-9227
University Hospital Cologne · DEForschungszentrum Jülich · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEvaluation of postoperative fractionated local 3D-conformal radiotherapy (3DRT) of the resection cavity in brain metastases. PATIENTS AND

methodsBetween 2011 and 2016, 57 patients underwent resection of a single, previously untreated (37/57, 65%) or recurrent (20/57, 35%) brain metastasis (median maximal diameter 3.5 cm [1.1-6.5 cm]) followed by 3DRT. For definition of the gross tumor volume (GTV), the resection cavity was used and for the clinical target volume (CTV), margins of 1.0-1.5 cm were added. Median dose was 48.0 Gy (30.0-50.4 Gy) in 25 (10-28) fractions; most patients had 36.0-42.0 Gy in 3.0 Gy fractions (n = 16, EQD2

resultsMedian follow-up was 18 months. Local control rates were 83% at 1 year and 78% at 2 years and were significantly influenced by histology (breast cancer 100%, non-small lung cancer 87%, melanoma 80%, colorectal cancer 26% at 2 years, p = 0.006) and resection status (p < 0.0001), but not by EQD2

conclusionAdjuvant fractionated local 3DRT is highly effective in radiosensitive, completely resected metastases and should be considered for treating large resection cavities as an alternative to postoperative stereotactic single dose or hypofractionated radiosurgery.

Indexed as

Brain NeoplasmsDose Fractionation, RadiationAdultHumansKarnofsky Performance StatusRadiotherapy, ConformalRetrospective StudiesTreatment OutcomeBreast cancerMalignant melanomaNeoplasm metastasisNon-small cell lung cancerSurvival analysis

Identifiers

PMID30218137
OpenAlexW2891727698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.