Evidence map›Paper›PMID 30218136›Full record

ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2018

Risk factors for brain metastasis in patients with small cell lung cancer without prophylactic cranial irradiation.

Yawen Zheng, Linlin Wang, Weichong Zhao, Yan Dou, Wei Lv, Hongyan Yang, Yuping Sun, Ligang Xing

Abstract read
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In one paragraph

Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 4 pooled it
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Article
  6. Development and validation of nomograms to predict brain metastasis-free survival in lung and breast cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
    Article
  7. Article
  8. Article
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  10. Survey of treatment and care practices in small-cell lung cancer among German radiation oncologists.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2023
    Article
  11. Article
  12. Article
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  15. Article
  16. Brain Metastasis in Patients with Small Cell Lung Cancer.International journal of general medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yawen ZhengDepartment of Oncology, Jinan Central Hospital, Shandong University, 250013, Jinan, Shandong, China.
Linlin WangDepartment of Radiation Oncology, Shandong Key Laboratory of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, No. 440 Jiyan Road, 250117, Jinan, Shandong, China.
Weichong ZhaoDepartment of Oncology, Jinan Central Hospital, Shandong University, 250013, Jinan, Shandong, China.
Yan DouDepartment of Oncology, Jinan Central Hospital, Shandong University, 250013, Jinan, Shandong, China.
Wei LvDepartment of Oncology, Jinan Central Hospital, Shandong University, 250013, Jinan, Shandong, China.
Hongyan YangDepartment of Oncology, Jinan Central Hospital, Shandong University, 250013, Jinan, Shandong, China.
Yuping SunDepartment of Oncology, Jinan Central Hospital, Shandong University, 250013, Jinan, Shandong, China.
Ligang XingDepartment of Radiation Oncology, Shandong Key Laboratory of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, No. 440 Jiyan Road, 250117, Jinan, Shandong, China. xinglg@medmail.com.cn.ORCID 0000-0002-9146-3048
Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to determine the risk factors for brain metastasis (BM) and the prognostic factors for overall survival (OS) in patients with small cell lung cancer without prophylactic cranial irradiation (PCI). PATIENTS AND

methodsLimited stage small cell lung cancer (LS-SCLC) patients achieving a complete response (CR) or partial response (PR) were enrolled into this study between January 2010 and December 2016. We retrospectively evaluated the influencing factors for time to BM and overall survival (OS).

resultsA total of 153 patients were enrolled into this study. Sixty-eight developed BM during the follow-up period. For the whole cohort, the 1‑ and 2‑year BM rates were 29.4 and 41.2%, respectively. Multivariate analysis showed that T stage (hazard ratio [HR] = 2.27, P = 0.024), neutrophil-to-lymphocyte ratio (NLR; HR = 2.07, P = 0.029), time to thoracic radiotherapy (HR = 0.34, P = 0.002) and chemotherapy cycles (HR = 0.49, P = 0.036) were the independent influencing factors of time to BM. Only NLR (HR = 2.11, P = 0.005) and time to thoracic radiotherapy (HR = 1.95, P = 0.011) were independent prognostic factors of OS. Of the 68 patients developing BM, those with BM occurring as the first relapse (42/68) had better OS than the others (39.5 months vs 23.0 months, P = 0.016).

conclusionLS-SCLC patients without PCI had a high risk of BM. High T stage, high NLR, early thoracic radiotherapy and fewer chemotherapy cycles were the risk factors of BM. Further research is needed to confirm the results.

Indexed as

Brain NeoplasmsCranial IrradiationLung NeoplasmsSmall Cell Lung CarcinomaHumansPositron Emission Tomography Computed TomographyProportional Hazards ModelsRetrospective StudiesRisk FactorsBrain metastasisNeutrophil-to-lymphocyte ratioProphylactic cranial irradiationRisk factorSmall cell lung cancer

Identifiers

PMID30218136
OpenAlexW2891507558

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.