Evidence map›Paper›PMID 30217944›Full record

ReviewBioscience reports2018

The regulatory roles of lncRNAs in the process of breast cancer invasion and metastasis.

Siying Zhou, Yunjie He, Sujin Yang, Jiahua Hu, Qian Zhang, Wei Chen, Hanzi Xu, Heda Zhang, Shanliang Zhong, Jianhua Zhao and 1 more

Abstract readReview
In one paragraph

Review in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. LncRNACancers · 2021
    Article
  16. Review
  17. Review
  18. Article
  19. A crucial role for the long non-coding RNAAmerican journal of translational research · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Siying ZhouThe First Clinical Medical College, Nanjing University of Chinese Medicine, Xianlin Road 138, Nanjing 210023, P.R. China.
Yunjie HeThe First Clinical School of Nanjing Medical University, Nanjing 210029, P.R. China.
Sujin YangThe First Clinical School of Nanjing Medical University, Nanjing 210029, P.R. China.
Jiahua HuThe Fourth Clinical School of Nanjing Medical University, Nanjing 210029, P.R. China.
Qian ZhangThe First Clinical School of Nanjing Medical University, Nanjing 210029, P.R. China.
Wei ChenDepartment of Head and Neck Surgery, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Baiziting 42, Nanjing 210029, P.R. China.
Hanzi XuDepartment of Radiotherapy, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Baiziting 42, Nanjing 210029, P.R. China.
Heda ZhangDepartment of General Surgery, School of Medicine, Southeast University, 87 Ding Jia Qiao, Nanjing 210009, P.R. China.
Shanliang ZhongCenter of Clinical Laboratory Science, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Baiziting 42, Nanjing 210029, P.R. China.
Jianhua ZhaoCenter of Clinical Laboratory Science, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Baiziting 42, Nanjing 210029, P.R. China jhtang@njmu.edu.cn lcjyjhzhao@126.com.
Jinhai TangDepartment of General Surgery, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, P.R. China jhtang@njmu.edu.cn lcjyjhzhao@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer (BC) is the most common cancer and principal cause of death among females worldwide. Invasion and metastasis are major causes which influence the survival and prognosis of BC. Therefore, to understand the molecule mechanism underlying invasion and metastasis is paramount for developing strategies to improve survival and prognosis in BC patients. Recent studies have reported that long non-coding RNAs (lncRNAs) play critical roles in the regulation of BC invasion and metastasis through a variety of molecule mechanisms that endow cells with an aggressive phenotype. In this article, we focused on the function of lncRNAs on BC invasion and metastasis through participating in epithelial-to-mesenchymal transition, strengthening cancer stem cells generation, serving as competing endogenous lncRNAs, influencing multiple signaling pathways as well as regulating expressions of invasion-metastasis related factors, including cells adhesion molecules, extracellular matrix, and matrix metallo-proteinases. The published work described has provided a better understanding of the mechanisms underpinning the contribution of lncRNAs to BC invasion and metastasis, which may lay the foundation for the development of new strategies to prevent BC invasion and metastasis.

Indexed as

Breast NeoplasmsCell MovementFemaleGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansNeoplasm InvasivenessNeoplasm MetastasisPrognosisRNA, Long NoncodingRNA, Long NoncodingBreast cancer (BC)InvasionLong non-coding RNAs (lncRNAs)Metastasis

Identifiers

PMID30217944
PMCPMC6165837

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.