ArticleProceedings of the National Academy of Sciences of the United States of America2018
Interleukin-22 promotes phagolysosomal fusion to induce protection against
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 49 citations in OpenAlex.
- Exploring microorganism-host interactions: Emerging organoid models and analytical approaches.mLife · 2026Review
- Modeling cancer-microbiome interactions in vitro: A guide to co-culture platforms.International journal of cancer · 2025Review
- Article
- Endosomal catabolism of phosphatidylinositol 4,5-bisphosphate is fundamental in building resilience against pathogens.Protein & cell · 2025Article
- The use of stem cells and organoids for modeling host-microbe interactions in low-biomass tissues.Frontiers in cellular and infection microbiology · 2025Review
- IL-22 in Atopic Dermatitis.Cells · 2024Review
- Advancements in understanding bacterial enteritis pathogenesis through organoids.Molecular biology reports · 2024Review
- Differential Salmonella Typhimurium intracellular replication and host cell responses in caecal and ileal organoids derived from chicken.Veterinary research · 2023Article
- Bioengineered Co-culture of organoids to recapitulate host-microbe interactions.Materials today. Bio · 2022Review
- Pathogenesis and virulence ofVirulence · 2022Review
- A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility.NPJ genomic medicine · 2022Article
- Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation.Cell stem cell · 2022Article
- Cross-Talk Between the Intestinal Epithelium andFrontiers in microbiology · 2022Review
- STAT1 coordinates intestinal epithelial cell death during gastrointestinal infection upstream of Caspase-8.Mucosal immunology · 2022Article
- Intestinal Organoids: New Tools to Comprehend the Virulence of Bacterial Foodborne Pathogens.Foods (Basel, Switzerland) · 2022Review
- Review
- Infections in the monogenic autoimmune syndrome APECED.Current opinion in immunology · 2021Review
- Organoids as host models for infection biology - a review of methods.Experimental & molecular medicine · 2021Review
- IL10RB as a key regulator of COVID-19 host susceptibility and severity.medRxiv : the preprint server for health sciences · 2021Article
- Advances in modelling the human microbiome-gut-brain axis in vitro.Biochemical Society transactions · 2021Review
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 2 countries.
Funding
Abstract
Intestinal epithelial cells (IECs) play a key role in regulating immune responses and controlling infection. However, the direct role of IECs in restricting pathogens remains incompletely understood. Here, we provide evidence that IL-22 primed intestinal organoids derived from healthy human induced pluripotent stem cells (hIPSCs) to restrict
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.