Evidence map›Paper›PMID 30217892›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Functional diversification of the NleG effector family in enterohemorrhagic

Dylan Valleau, Dustin J Little, Dominika Borek, Tatiana Skarina, Andrew T Quaile, Rosa Di Leo, Scott Houliston, Alexander Lemak, Cheryl H Arrowsmith, Brian K Coombes and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Identification of candidate nucleomodulins in ESKAPE bacteria -Frontiers in cellular and infection microbiology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. A Search for NovelFrontiers in cellular and infection microbiology · 2022
    Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. TheLife science alliance · 2019
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Dylan ValleauDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada.ORCID 0000-0002-1067-9067
Dustin J LittleDepartment of Biochemistry and Biomedical Sciences, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada.
Dominika BorekDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-4321-6253
Tatiana SkarinaDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada.
Andrew T QuaileDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada.ORCID 0000-0002-1194-3712
Rosa Di LeoDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada.
Scott HoulistonPrincess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 2M9, Canada.
Alexander LemakPrincess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 2M9, Canada.
Cheryl H ArrowsmithPrincess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 2M9, Canada.
Brian K CoombesDepartment of Biochemistry and Biomedical Sciences, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada.
Alexei SavchenkoDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada; alexei.savchenko@ucalgary.ca.
University of Toronto · CAMcMaster University · CAThe University of Texas Southwestern Medical Center · USUniversity of Calgary · CA

Funding

Canadian Institutes of Health ResearchNIAID NIH HHS HHSN272201200026CNIAID NIH HHS HHSN272201700060C
6 · The paper itself

Abstract

The pathogenic strategy of

Indexed as

Escherichia coli O157Escherichia coli ProteinsEscherichia coli InfectionsHEK293 CellsHeLa CellsHexokinaseHumansMediator ComplexProtein DomainsProteolysisQb-SNARE ProteinsQc-SNARE ProteinsU937 CellsEscherichia coli ProteinsHexokinaseHK2 protein, humanMED15 protein, humanMediator ComplexQb-SNARE ProteinsQc-SNARE ProteinsSNAP29 protein, humaneffectorsEscherichia colipathogenesisubiquitination

Identifiers

PMID30217892
PMCPMC6176568
OpenAlexW2891272768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.