Evidence map›Paper›PMID 30217846›Full record

ArticleApplied and environmental microbiology2018

Poisoning with Soman, an Organophosphorus Nerve Agent, Alters Fecal Bacterial Biota and Urine Metabolites: a Case for Novel Signatures for Asymptomatic Nerve Agent Exposure.

Derese Getnet, Aarti Gautam, Raina Kumar, Allison Hoke, Amrita K Cheema, Franco Rossetti, Caroline R Schultz, Rasha Hammamieh, Lucille A Lumley, Marti Jett

Open access · bronzeAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Derese Getnet *Integrative Systems Biology Program, U.S. Army Center for Environmental Health Research, Fort Detrick, Maryland, USA.ORCID 0000-0002-2619-4910
Aarti Gautam *Integrative Systems Biology Program, U.S. Army Center for Environmental Health Research, Fort Detrick, Maryland, USA.ORCID 0000-0003-3132-5599
Raina Kumar *Integrative Systems Biology Program, U.S. Army Center for Environmental Health Research, Fort Detrick, Maryland, USA.
Allison HokeIntegrative Systems Biology Program, U.S. Army Center for Environmental Health Research, Fort Detrick, Maryland, USA.
Amrita K CheemaDepartments of Oncology and Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC, USA.
Franco RossettiClinical Research Management, Silver Spring, Maryland, USA.
Caroline R SchultzEdmond Scientific Company, Aberdeen Proving Ground, Maryland, USA.
Rasha HammamiehIntegrative Systems Biology Program, U.S. Army Center for Environmental Health Research, Fort Detrick, Maryland, USA.
Lucille A LumleyU.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, USA.
Marti JettIntegrative Systems Biology Program, U.S. Army Center for Environmental Health Research, Fort Detrick, Maryland, USA marti.jett-tilton.civ@mail.mil.
Center for Environmental Health · USCECOM Software Engineering Center · USClinical Research Management · USGeorgetown University · USUnited States Army · US

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI STEPHEN W BYERS · 1990 to 2026
$71.5M
NCI NIH HHS P30 CA051008
6 · The paper itself

Abstract

The experimental pathophysiology of organophosphorus (OP) chemical exposure has been extensively reported. Here, we describe an altered fecal bacterial biota and urine metabolome following intoxication with soman, a lipophilic G class chemical warfare nerve agent. Nonanesthetized Sprague-Dawley male rats were subcutaneously administered soman at 0.8 (subseizurogenic) or 1.0 (seizurogenic) of the 50% lethal dose (LD

Indexed as

AnimalsBacteriaBiotaFecesHumansMaleNerve AgentsRatsRats, Sprague-DawleySeizuresSomanUrineNerve AgentsSoman16S rRNA genegut microbiomesomanurine metabolome

Identifiers

PMID30217846
PMCPMC6193380
OpenAlexW2891294987

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.