SynthesisJournal of the American Society of Nephrology : JASN2018
Genetic Variants Associated with Circulating Fibroblast Growth Factor 23.
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In one paragraph
Synthesis in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
What it found
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Review
- TGFβ signaling regulates the response of the skeleton to phosphate.bioRxiv : the preprint server for biology · 2025Article
- Pathophysiology of chronic kidney disease-mineral bone disorder (CKD-MBD): from adaptive to maladaptive mineral homeostasis.Clinical kidney journal · 2025Article
- Genetic association of serum calcium, phosphate, vitamin D, parathyroid hormone, and FGF23 with the risk of aortic stenosis.NPJ cardiovascular health · 2024Article
- Fibroblast growth factor 23-mediated regulation of osteoporosis: Assessed via Mendelian randomization and in vitro study.Journal of cellular and molecular medicine · 2024Article
- Variation in the fibroblast growth factor 23 (Frontiers in genetics · 2023Article
- Interaction of Vitamin D with Peptide Hormones with Emphasis on Parathyroid Hormone, FGF23, and the Renin-Angiotensin-Aldosterone System.Nutrients · 2022Review
- Genetic Variants Associated With Mineral Metabolism Traits in Chronic Kidney Disease.The Journal of clinical endocrinology and metabolism · 2022Article
- Fibroblast growth factor 23-Klotho and hypertension: experimental and clinical mechanisms.Pediatric nephrology (Berlin, Germany) · 2021Review
- RGS14 Regulation of Post-Synaptic Signaling and Spine Plasticity in Brain.International journal of molecular sciences · 2021Review
- The complex interplay between kidney injury and inflammation.Clinical kidney journal · 2021Review
- Genetically Predicted Fibroblast Growth Factor 23 and Major Cardiovascular Diseases, Their Risk Factors, Kidney Function, and Longevity: A Two-Sample Mendelian Randomization Study.Frontiers in genetics · 2021Article
- Growth Factors and Their Roles in Multiple Sclerosis Risk.Frontiers in immunology · 2021Article
- Genome-wide association study for circulating fibroblast growth factor 21 and 23.Scientific reports · 2020Article
- Association of Fibroblast Growth Factor 23 With Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study.Frontiers in genetics · 2020Article
- Higher Fibroblast Growth Factor 23 Levels Are Causally Associated With Lower Bone Mineral Density of Heel and Femoral Neck: Evidence From Two-Sample Mendelian Randomization Analysis.Frontiers in public health · 2020Article
- Genome-wide Association Study of 24-Hour Urinary Excretion of Calcium, Magnesium, and Uric Acid.Mayo Clinic proceedings. Innovations, quality & outcomes · 2019Article
- Clinical aspects of the phosphate transporters NaPi-IIa and NaPi-IIb: mutations and disease associations.Pflugers Archiv : European journal of physiology · 2019Review
- Fibroblast Growth Factor 23 Genotype and Cardiovascular Disease in Patients Undergoing Hemodialysis.American journal of nephrology · 2019Article
- AAging · 2018Article
Corrections and comments
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Authors and funding
27 authors at 13 institutions in 3 countries.
Cassianne Robinson-CohenDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; cassianne.robinson-cohen@vumc.org.ORCID 0000-0003-4783-7046
Traci M BartzCardiovascular Health Research Unit, Departments of Biostatistics and Medicine.
Dongbing LaiDepartments of Medical and Molecular Genetics and.
T Alp IkizlerDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Munro PeacockMedicine, Indiana University, Indianapolis, Indiana.
Erik A ImelMedicine, Indiana University, Indianapolis, Indiana.
Erin D MichosDivision of Cardiology, Johns Hopkins School of Medicine, Baltimore, Maryland.
Tatiana M ForoudDepartments of Medical and Molecular Genetics and.
Kristina AkessonClinical and Molecular Osteoporosis Research Unit, Department of Clinical Science Malmö, Lund University, Malmö, Sweden.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles Medical Center, Torrance, California.
Linnea MalmgrenClinical and Molecular Osteoporosis Research Unit, Department of Clinical Science Malmö, Lund University, Malmö, Sweden.
Kunihiro MatsushitaDivision of Cardiology, Johns Hopkins School of Medicine, Baltimore, Maryland.
Maria NethanderDepartment of Medicine, Bioinformatics Core Facility and.
Joel ErikssonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Claes OhlssonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Daniel MellströmCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Myles WolfDivision of Nephrology, Department of Medicine, and Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina.
Osten LjunggrenDepartment of Medical Sciences, Endocrinology and Mineral Metabolism, Uppsala University, Uppsala, Sweden.
Fiona McGuiganClinical and Molecular Osteoporosis Research Unit, Department of Clinical Science Malmö, Lund University, Malmö, Sweden.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles Medical Center, Torrance, California.
Magnus KarlssonClinical and Molecular Osteoporosis Research Unit, Department of Clinical Science Malmö, Lund University, Malmö, Sweden.
Michael J EconsDepartments of Medical and Molecular Genetics and.
Joachim H IxDivision of Nephrology-Hypertension, Department of Medicine, University of California San Diego, San Diego, California.
Pamela L LutseyDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Epidemiology, Health Services and Medicine, and.
Ian H de BoerKidney Research Institute, Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington.ORCID 0000-0003-1571-7592
Bryan R KestenbaumKidney Research Institute, Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington.ORCID 0000-0003-4799-5968
Lund University · SEIndiana University – Purdue University Indianapolis · USUniversity of Gothenburg · SEJohns Hopkins University · USUniversity of California, Los Angeles · USUniversity of Washington · USVanderbilt University Medical Center · USBioinformatics Institute · SGDuke University · USKaiser Permanente Washington Health Research Institute · USUniversity of California San Diego · USUniversity of Minnesota · USUppsala University · SE
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MOregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MZOSUQUIDAR TRIHYDROCHLORIDE DURING CONVENTIONAL INDUCTION AND POST-REMISSIONM01RR000750 · NCRR · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI STORNIOLO, ANNA · 1985 to 2008
$25.5MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MINDIANA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE (UL1): BPCAUL1RR025761 · NCRR · INDIANA UNIVERSITY INDIANAPOLIS · PI SHEKHAR, ANANTHA · 2008 to 2011
$21.0MGENETICS OF BONE LOSS AND BONE STRENGTH IN WOMEN &MENP01AG018397 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI ECONS, MICHAEL J · 2000 to 2010
$19.1MUCLA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033176 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$15.5MNCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR000128NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NCRR NIH HHS M01 RR000750NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1 RR025761NCRR NIH HHS UL1 RR033176NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004402NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL071051NHLBI NIH HHS R01 HL071205NHLBI NIH HHS R01 HL071250NHLBI NIH HHS R01 HL071251NHLBI NIH HHS R01 HL071258NHLBI NIH HHS R01 HL071259NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL096875NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL103706NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIAMS NIH HHS K23 AR057096NIAMS NIH HHS P30 AR072581NIAMS NIH HHS R21 AR061078NIAMS NIH HHS U01 AR066160NIA NIH HHS P01 AG018397NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG041517NIA NIH HHS U01 AG027810NIA NIH HHS U01 AG042124NIA NIH HHS U01 AG042139NIA NIH HHS U01 AG042140NIA NIH HHS U01 AG042143NIA NIH HHS U01 AG042145NIA NIH HHS U01 AG042168NIDDK NIH HHS K01 DK109019NIDDK NIH HHS P30 DK063491
Abstract
backgroundFibroblast growth factor 23 (FGF23), a bone-derived hormone that regulates phosphorus and vitamin D metabolism, contributes to the pathogenesis of mineral and bone disorders in CKD and is an emerging cardiovascular risk factor. Central elements of FGF23 regulation remain incompletely understood; genetic variation may help explain interindividual differences.
methodsWe performed a meta-analysis of genome-wide association studies of circulating FGF23 concentrations among 16,624 participants of European ancestry from seven cohort studies, excluding participants with eGFR<30 ml/min per 1.73 m
resultsWe discovered 154 SNPs from five independent regions associated with FGF23 concentration. The SNP with the strongest association, rs17216707 (
conclusionsCommon genetic variants located near genes involved in vitamin D metabolism and renal phosphate transport are associated with differences in circulating FGF23 concentrations.
Indexed as
Polymorphism, Single NucleotideBlack PeopleCohort StudiesFemaleFibroblast Growth Factor-23Fibroblast Growth FactorsGenome-Wide Association StudyHumansKidneyMalePhosphatesRGS ProteinsSodium-Phosphate Cotransporter Proteins, Type IIaVitamin DVitamin D3 24-HydroxylaseWhite PeopleCYP24A1 protein, humanFGF23 protein, humanFibroblast Growth Factor-23Fibroblast Growth FactorsPhosphatesRGS14 protein, humanRGS ProteinsSLC34A1 protein, humanSodium-Phosphate Cotransporter Proteins, Type IIaVitamin DVitamin D3 24-Hydroxylasefibroblast growth factor 23human geneticsmineral metabolism
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