ArticleBrain, behavior, and immunity2018
Negative and positive affect as predictors of inflammation: Timing matters.
Article in Brain, behavior, and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 76 citations in OpenAlex.
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- Examining daily affect variability by individual differences among a diverse community sample.Emotion (Washington, D.C.) · 2026Article
- Negative affect and peripheral inflammation: The role of cognitive reappraisal and expressive suppression.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Childhood Maltreatment and Cognitive Performance in Bipolar Disorder: The Potential Role of Inflammation.Acta psychiatrica Scandinavica · 2026Article
- Systemic inflammation and ex vivo inflammatory responses in first semester university students.Psychoneuroendocrinology · 2026Article
- Psychological stress and social support are associated with opposing single-cell pro-inflammatory gene regulatory mechanisms in adults.bioRxiv : the preprint server for biology · 2025Article
- Decomposing the association of psychosocial wellbeing with all-cause mortality: the mediating role of physical health and lifestyle factors.Social psychiatry and psychiatric epidemiology · 2025Article
- Salivary Immunoglobulin a Alterations in Health and Disease: A Bibliometric Analysis of Diagnostic Trends from 2009 to 2024.Antibodies (Basel, Switzerland) · 2024Article
- Moving toward affective immunology: Legacy and future directions.Comprehensive psychoneuroendocrinology · 2024Article
- Association between psychosocial factors and C-reactive protein across income, race, and sex.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024Article
- Older adults' self-reported prospective memory lapses in everyday life: Connections to inflammation and gender.Journal of psychosomatic research · 2023Article
- The incidence, impact, and risk factors for moderate to severe persistent pain after breast cancer surgery: a prospective cohort study.Pain medicine (Malden, Mass.) · 2023Article
- Exploring the emotional impact of axial Spondyloarthritis: a systematic review and thematic synthesis of qualitative studies and a review of social media.BMC rheumatology · 2023Article
- The future is dynamic: A call for intensive longitudinal data in immunopsychiatry.Brain, behavior, and immunity · 2023Article
- Heightened inflammation in bipolar disorder occurs independent of symptom severity and is explained by body mass index.Brain, behavior, & immunity - health · 2023Article
- Mean affect and affect variability may interact to predict inflammation.Brain, behavior, and immunity · 2023Article
- Hierarchical Inflammatory Phenotypes of Depression: A Novel Approach Across Five Independent Samples and 27,730 Adults.Biological psychiatry · 2023Article
- Article
- Validation of a novel method of ultraviolet-induced cutaneous inflammation and its associations with anhedonia.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Very little research has assessed how measures of negative and positive affect (NA and PA) derived from assessments at multiple time points per day (e.g., via ecological momentary assessment [EMA]), as opposed to questionnaires that rely on recall over a longer period, are related to levels of peripheral inflammation. We examined how different indicators of NA and PA predicted concentrations of C-reactive protein (CRP) and seven peripheral inflammatory cytokines (IL-1β, IL-6, TNF-α, IL-8, IL-4, IL-10, and IFN-γ) that were examined in the form of an inflammatory composite. A community-based sample of 220 adults (62% Black/African-American and 25% Hispanic/Latino; aged 25-65; 65% female) completed questionnaires at baseline (including recalled affect "over the past month") and then provided EMA reports 5x/day for 14 days. Blood was drawn from each participant after completion of EMA and used to determine plasma levels of CRP and cytokines. Analyses examined if indicators of affect predicted inflammation, controlling for age, gender, body mass index, education, health conditions, and statin use. Neither recalled NA or PA nor momentary NA or PA (aggregated across the 14 days of EMA) were significantly associated with the cytokine composite or CRP. Negative mood more proximal to the blood draw (i.e., aggregated momentary NA in week 2 of EMA) was associated with the cytokine composite but not CRP. Exploratory moderation analyses revealed that the cytokine composite was also associated with PA in week 2 for men only, and with recalled NA for those with lower education. Exploratory analyses around temporal dynamics suggested that the timing of NA measurement relative to the blood draw mattered: Specifically, there were stronger trends of association between momentary NA and inflammatory cytokines when NA was assessed closer in time to blood collection. Future investigation of the relevance of temporal proximity and other measurement details may improve understanding of how affect relates to inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.