ArticleBrain, behavior, and immunity2018
Pathways linking childhood abuse history and current socioeconomic status to inflammation during pregnancy.
Article in Brain, behavior, and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Childhood abuse and perinatal outcomes for mother and child: A systematic review of the literature.PloS one · 2024Pooled it
- A sum of its parts: A systematic review evaluating biopsychosocial and behavioral determinants of perinatal depression.PloS one · 2024Pooled it
- The association of child maltreatment and systemic inflammation in adulthood: A systematic review.PloS one · 2021Pooled it
- From childhood to adult trauma and negative birth experiences: distal and proximal factors associated with childbirth-related posttraumatic stress symptoms.European journal of psychotraumatology · 2026Article
- Examining the association between prenatal inflammation and postpartum depression in a large, prospective pregnancy cohort in New York City.Brain, behavior, and immunity · 2026Article
- Maternal adversity and peripheral proinflammatory cytokine concentrations in pregnancy.Brain, behavior, & immunity - health · 2026Article
- Chronic emotional stress and mediating role of Interleukin-6 in the association with cardiometabolic disorders in a multiethnic middle-aged and older US population.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Estimating the associations between women's maltreatment in childhood and inflammatory biomarker levels prior to and during pregnancy.PloS one · 2025Article
- A Brief Historic Review of Research on Early Life Stress and Inflammation across the Lifespan.Neuroimmunomodulation · 2025Review
- Maternal immune response during pregnancy and neurodevelopmental outcomes: A longitudinal approach.Brain, behavior, & immunity - health · 2024Article
- Prenatal mood and anxiety disorders and associated cytokine changes.Journal of affective disorders · 2024Article
- A sum of its parts: A systematic review evaluating biopsychosocial and behavioral determinants of perinatal depression.medRxiv : the preprint server for health sciences · 2023Article
- Associations Between Adverse Childhood Experiences and Stressful Life Events and Health Outcomes in Pregnant and Breastfeeding Women from Diverse Racial and Ethnic Groups.Journal of women's health (2002) · 2023Article
- Childhood Adversity Predicts Maternal Pre-Pregnancy BMI but not Gestational Weight Gain.Maternal and child health journal · 2023Article
- Is There an Inflammatory Profile of Perinatal Depression?Current psychiatry reports · 2023Review
- Lifetime stressor exposure, systemic inflammation during pregnancy, and preterm birth among Black American women.Brain, behavior, and immunity · 2022Article
- Exposure to childhood maltreatment and systemic inflammation across pregnancy: The moderating role of depressive symptomatology.Brain, behavior, and immunity · 2022Article
- Socioeconomic Status and Inflammation in Women with Early-stage Breast Cancer: Mediation by Body Mass Index.Brain, behavior, and immunity · 2022Article
- Women's Social Well-Being During Pregnancy: Adverse Childhood Experiences and Recent Life Events.Women's health reports (New Rochelle, N.Y.) · 2022Article
- Maternal prenatal choline and inflammation effects on 4-year-olds' performance on the Wechsler Preschool and Primary Scale of Intelligence-IV.Journal of psychiatric research · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Women who have experienced significant adversities during childhood and adulthood are at risk for excessive inflammation during pregnancy, but the mechanisms are unclear. Using structural equation modeling, we examined pathways from childhood abuse history and current socioeconomic status (SES) to inflammatory markers through indicators of health risk, recent stressors, and psychological distress in 214 women assessed at mid-pregnancy (5-31 weeks gestation). Self-reported data on socioeconomic indicators, childhood trauma history, pre-pregnancy body mass index (BMI), smoking, sleep quality, interpersonal conflict, recent life events, perceived stress, and depressive symptoms were collected, and serum levels of C-reactive protein (CRP) and interleukin (IL)-6 were determined. In separate models, pre-pregnancy BMI, sleep quality, and interpersonal conflict statistically explained the relationship between adversity and inflammation. These three intermediate variables were then entered into a multiple mediation analysis to examine unique effects. Childhood abuse history and current SES both demonstrated significant indirect effects on CRP through pre-pregnancy BMI, and current SES showed a significant indirect effect on IL-6 through all intermediate variables. When examining each indirect pathway individually, pre-pregnancy BMI and interpersonal conflict emerged as parallel pathways by which low current SES leads to elevated IL-6; the indirect pathway through sleep quality was no longer significant. Pre-pregnancy BMI and interpersonal conflict are two independent mechanisms by which adversity is associated with increased inflammation during pregnancy. Women who have been exposed to significant adversity may be at particular risk for obesity, sleep disruption, and interpersonal conflict, with implications for immune dysregulation during pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.